Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome - 28/01/19
Doi : 10.1016/j.ccm.2018.10.016
Philip E. Silkoff, MD a, ⁎ 
, Wendy C. Moore, MD b, Peter J. Sterk, MD, PhD c
, Wendy C. Moore, MD b, Peter J. Sterk, MD, PhD c a 827 North 21st Street, Philadelphia, PA 19130, USA
b Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
c Department of Respiratory Medicine F5-152, Amsterdam UMC, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
∗Corresponding author.
Résumé |
The SARP, ADEPT, and U-BIOPRED programs are all significant efforts in characterizing asthma and reporting clusters that will assist in designing personalized therapies for asthma, and especially severe asthma. Key aspects of the design of these programs are summarized and major findings are reported in this review.
Le texte complet de cet article est disponible en PDF.Keywords : Asthma, Endotypes, Phenotypes, Clustering, Biomarkers
Plan
| Disclosure Statement: P.J. Sterk: The Amsterdam UMC has received a public-private grant by the Innovative Medicines Initiative (IMI) for the U-BIOPRED Study, covered by the European Union (EU) and the European Federation of Pharmaceutical Industries and Associations (EFPIA). P.E. Silkoff: P.E. Silkoff is a full-time employee of Third Pole Inc and declares no conflict of interest regarding the content of this article. W.C. Moore has received funding by the National Heart, Lung and Blood Institute (NHLBI) or the National Institutes of Health (NIH), USA for the SARP program. |
© 2018
Elsevier Inc. Tous droits réservés.
Vol 40 - N° 1
P. 13-28 - mars 2019 Retour au numéro
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