Microbiome in Mechanisms of Asthma - 28/01/19
, Rhonda Alkatib, MD, Monica Kraft, MDRésumé |
The lung and gut microbiome are factors in asthma risk or protection. Relevant elements of the microbiome within both niches include the importance of the early life window for microbiome establishment, the diversity of bacteria, richness of bacteria, and effect of those bacteria on the local epithelium and immune system. Mechanisms of protection include direct anti-inflammatory action or induction of non–type 2 inflammation by certain bacterial colonies. The gut microbiome further impacts asthma risk through the contribution of metabolic products. This article reviews the mechanisms that connect the lung and gut microbiota to asthma development and severity.
Le texte complet de cet article est disponible en PDF.Keywords : Microbiome, Asthma, Lung, Gut, Short-chain fatty acids, Type 2 inflammation
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| Disclosure Statement: Dr T.F. Carr reports royalties from Wolters-Kluwer; and has provided consulting services to Sanofi-Regeneron, AstraZeneca, and Boehringer Ingelheim. Dr R. Alkatib has no disclosures to report. Dr M. Kraft reports royalties from Elsevier; has received research funds paid to the University of Arizona by National Institutes of Health, American Lung Association, Sanofi-Regeneron, and Chiesi; and has provided consulting services to Astra-Zeneca, Sanofi-Regeneron, and TEVA Pharmaceuticals. |
Vol 40 - N° 1
P. 87-96 - mars 2019 Retour au numéro
Article précédent
- Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity
- Octavian C. Ioachimescu, Nikita S. Desai
- Diet and Metabolism in the Evolution of Asthma and Obesity
- Anne E. Dixon, Fernando Holguin
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