Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers - 27/02/19

Doi : 10.1016/j.pediatrneurol.2018.10.007

Yun Zhang, MM ^a,^e, Jing Yang, MB ^b,^e, Wei Jiang, PhD, MD ^c,^e, Rong Li, MM ^d,^e, Min Zhu, MM ^d,^e, Feng Xiong, MM ^d,^e, Cui Song, MD ^d,^e,^⁎
^a Radiology Department, Children’s Hospital of Chongqing Medical University, Chongqing, China
^b Center for Clinical Molecular Medicine, Children’s Hospital of Chongqing Medical University, Chongqing, China
^c Rehabilitation Department, Children’s Hospital of Chongqing Medical University, Chongqing, China
^d Department of Endocrinology and Genetic Metabolic Disease, Children’s Hospital of Chongqing Medical University, Chongqing, China
^e Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, China

^⁎Communications should be addressed to: Song; Department of Endocrinology and Genetic Metabolic Disease, Children’s Hospital of Chongqing Medical University, No. 136 Zhongshan ER Road, Chongqing 400014, China.Department of Endocrinology and Genetic Metabolic DiseaseChildren’s Hospital of Chongqing Medical UniversityNo. 136 Zhongshan ER RoadChongqing400014China

Abstract

Background

Down syndrome (DS) is a neurodegenerative disease with unknown mechanisms. β-Amyloid peptide (Aβ) and tau protein (Tau) are known to play a role, while vitamin A (VA) has an effect on normal neurological function. In a case-control study, we quantitatively evaluated whole brain and hippocampal volumes of DS children and analyzed the correlation of hippocampal volumes with blood levels of Aβ, Tau and VA.

Methods

All subjects underwent magnetic resonance imaging (MRI) of the brain. The whole brain and hippocampal volumes were quantitatively analyzed using voxel-based morphometry (VBM) and stereology respectively. The blood levels of Aβ, Tau, and VA were detected by enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively.

Results

Thirty DS children and twenty healthy controls were recruited. Whole brain and hippocampal volumes were significantly smaller in individuals with DS than in healthy controls. In both groups, whole brain and hippocampal volumes increased in accordance with age. The results of correlation analysis suggested that Aβ42/Aβ40 and VA are associated with hippocampal volume in DS patients.

Conclusion

DS children exhibited neurodevelopmental defects, even at an early age. Aβ42/Aβ40 and VA may affect hippocampal volume in DS patients.

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Keywords : Down syndrome, Neurodegenerative disease, β-amyloid peptide, Vitamin A

Plan

Introduction

Material and methods

Participants

Cranial imaging examination

Blood collection and laboratory measurements

	Funding: This research was supported by National Natural Science Foundation of China (81600690), Jin Lei Pediatric Endocrinology Growth Research Fund for Young Physicians (PEGRF201607008).
	Disclosure: The authors declare that they have no conflict of interest.

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Vol 92

P. 43-47 - mars 2019 Retour au numéro

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Brain Development Measured With MRI in Children With Down Syndrome Correlates With Blood Biochemical Biomarkers - 27/02/19

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