Ovarian Function in Adolescents Conceived Using Assisted Reproductive Technologies - 03/03/19
, Patricia Lopez, BSc 1, 2, Abril Salinas, MD, PhD 1, Carolina Pastene, MD 3, Alex Muñoz, BSc 1, 2, Fernando Cassorla, MD 1, Ethel Codner, MD 1Abstract |
Study Objective |
To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).
Design |
Multicenter study of ovarian function in AcART because of male or tubal infertility.
Setting |
University Hospital.
Participants |
We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. The participants were born at term (≥37 weeks of gestation) with normal birth weights (≥2500 g) from singleton pregnancies.
Interventions |
None.
Main Outcome Measures |
Differences in ovulation, reproductive hormones, and ovarian morphology.
Results |
AcART had an older age of menarche than that of AcSP, even after adjusting for maternal age at menarche, gestational age, and birth weight (P = .027). AcART had lower incidence of ovulation (P = .021) and higher luteinizing hormone serum levels (P = .01) than those of AcSP. The incidence of oligomenorrhea and the cycle length were similar between AcART and AcSP. AcART had levels of anti-Müllerian hormone, inhibin B, follicle-stimulating hormone, estradiol, and androgens similar to those of AcSP. The ovarian morphology, ovarian volume, and follicle counts were similar in both groups.
Conclusion |
AcART had later menarche, lower ovulation rates, and higher luteinizing hormone levels than those of AcSP. Future studies should investigate whether these findings are indicative of a risk of ovarian dysfunction later in life for AcART.
Le texte complet de cet article est disponible en PDF.Key Words : Ovulation rate, Inhibin B, Anti-Müllerian hormone, Age of menarche, IVF offspring, Assisted reproductive technology
Plan
| The authors indicate no conflicts of interest. |
Vol 32 - N° 2
P. 117-121 - avril 2019 Retour au numéro
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