Intraoperative macroscopic tumour consistency is associated with overall survival after cytoreductive surgery and intraperitoneal chemotherapy for appendiceal adenocarcinoma with peritoneal metastases: A retrospective observational study - 14/03/19
Abstract |
Background |
This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases.
Methods |
Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared.
Results |
The three groups had similar perioperative short-term outcomes. Patients with soft, intermediate and hard tumours revealed differences in OS (p < 0.001) and DFS (p = 0.03). Multivariable analysis revealed a shorter OS for patients with hard versus soft tumours (HR for hard tumours = 4.43, 95%CI 2.19–9.00).
Conclusions |
Intraoperative macroscopic tumour consistency may be used as a prognostic marker for survival in patients with appendiceal adenocarcinoma with peritoneal metastases.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Microscopic features of tumours play important roles in prognosis. |
• | Intraoperative macroscopic features vary among tumours |
• | This paper identifies that intraoperative tumour consistency is a prognostic marker for long-term survival in patients undergoing CRS/HIPEC. |
Keywords : Consistency, Tumour characteristics, Appendix, Peritoneal metastases, Cytoreductive surgery
Plan
Vol 217 - N° 4
P. 704-712 - avril 2019 Retour au numéro
Article précédent
- Risk of adhesive bowel obstruction after abdominal surgery. A national cohort study of 665,423 Danish women
- Christina Norrbom, Marianne Steding-Jessen, Carsten Thye Agger, Merete Osler, Marie Krabbe-Sorensen, Annette Settnes, Lisbeth Nilas, Ellen Christine Leth Loekkegaard
- Complicated appendicitis: Immediate operation or trial of nonoperative management?
- Neha Nimmagadda, Kazuhide Matsushima, Alice Piccinini, Caroline Park, Aaron Strumwasser, Lydia Lam, Kenji Inaba, Demetrios Demetriades
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?