The utilization of embryonic stem cells has ethical problems regarding the use of embryos in cell therapy and regenerative medicine, especially in neurodegenerative diseases. To overcome these ethical issues, induced Pluripotent Stem Cells and then transdifferentiation have presented to the science world which can be a good shortcut and solution to the ethical issues of traditional methods. Neurodegenerative diseases are difficult puzzles to combine and with modeling of these diseases by somatic cells reprogramming such as induced pluripotent stem cells induction or direct differentiation techniques, this could be solved. In the present study, we briefly review the techniques which used for neurodegenerative diseases’ researches.