Obesity, dynapenia and high cardiovascular risk co-exist in post-liver transplant setting: results of a cross-sectional study - 03/04/19
, Juliana Paula Bruch-Bertani a, Clara Belle Manfroi Galinatti b, Claudia Czarnobay Garbin a, Mário Reis Álvares-da-Silva a, c, Valesca Dall’Alba a, dBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 8 |
| Iconographies | 1 |
| Vidéos | 0 |
| Autres | 0 |
Highlights |
• | One of the first studies to evaluate cardiovascular risk by carotid intima-media thickness in liver transplantation patients. |
• | Nutritional assessment of liver transplantation patients, including dynapenia, sarcopenia and obesity prevalence. |
• | High-sensitivity C-reactive protein and dietary intake of trans fatty acids were associated with abnormal carotid intima-media thickness. |
Summary |
Background |
Cardiovascular disease is a major cause of death in post-liver transplantation (LT). The aim of this study was to evaluate LT patients as to the carotid intima-media thickness (CIMT) and its association with nutritional status, dietary intake, metabolic profile and cardiovascular risk factors.
Methods |
In this cross-sectional study, adult patients with more than 12 months of post-transplant follow-up underwent clinical, laboratory, functional and nutritional evaluation by 3-day-diet-record, anthropometry and dynamometry. CIMT was evaluated by Doppler ultrasonography.
Results |
Sixty-nine post-LT patients [males 61%, median of age 59 (51–64) years were included; median time post-liver transplantation 2.8 (1.4–6.3) years]. High prevalence of malnutrition was found (45% of arm muscle area < p15 and 71% of handgrip strength < p30). Excess weight was present in 72% of patients, body mass index ≥ 30 kg/m2 in 35% and metabolic syndrome in 51%. Abnormal CIMT was found in 54% of the sample. Patients with abnormal CIMT presented higher cardiovascular risk Score, LDL cholesterol, higher prevalence of high-sensitive C-reactive protein ≥ 1 mg/L and higher intake of saturated and trans fatty acids (P < 0.05 for all).
Conclusions |
Abnormal IMT was commonly found in LT patients presenting at the same time with overweight and dynapemia. These results were associated with higher LDL-cholesterol levels, high-sensitive C-reactive protein ≥ 1 mg/L and higher intake of saturated and trans fatty acids. Preventive measures, including dietary advice, are required for all post-liver transplantation patients to minimize cardiovascular risk.
Le texte complet de cet article est disponible en PDF.Abbreviations : AC, ALP, ALT, AMA, AST, ASCVD, BMI, BP, CIMT, CP, CV, GGT, GI, GL, HDL, HS, hs-CRP, IPAQ, LDL, LT, METs, MS, TC, TG, TS, WC
Keywords : liver transplantation, carotid intima-media thickness, atherosclerotic plaque, metabolic profile, dynapenia, nutritional assessment
Plan
Vol 43 - N° 2
P. 140-147 - avril 2019 Retour au numéro
Article précédent
- Ischemic-type biliary lesions: A leading indication of liver retransplantation with excellent results
- Astrid Schielke, Olivier Scatton, Pierre-Yves Boelle, Fabiano Perdigao, Denis Bernard, Olivier Soubrane, Filomena Conti
- Outcome of the use of paediatric donor livers in adult recipients: A single Chinese centre experience
- Weiqiang Ju, Cheukfai Li, Chuanzhao Zhang, Dicken Shiu-Chung Ko, Dongping Wang, Ming Han, Paul M. Schroder, Xiaoping Wang, Xingyuan Jiao, Linwei Wu, Qiang Tai, Anbin Hu, Yi Ma, Xiaofeng Zhu, Zhiyong Guo, Xiaoshun He
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?