Acculturation is associated with asthma burden and pulmonary function in Latino youth: The GALA II study - 04/05/19
, Luisa N. Borrell, DDS, PhD b, Morgan Ye, MPH a, Sam S. Oh, PhD, MPH a, Celeste Eng, BS a, Kelley Meade, MD c, Pedro C. Avila, MD d, Harold J. Farber, MD, MSPH e, Denise Serebrisky, MD f, Emerita Brigino-Buenaventura, MD g, William Rodriguez-Cintron, MD h, Rajesh Kumar, MD, MSPH i, Kirsten Bibbins-Domingo, PhD, MD a, Shannon Thyne, MD j, Saunak Sen, PhD k, Jose R. Rodriguez-Santana, MD l, Esteban G. Burchard, MD, MPH a, mAbstract |
Background |
Acculturation is an important predictor of asthma in Latino youth, specifically Mexican Americans. Less is known about acculturation and pulmonary function measures.
Objective |
We sought to estimate the association of acculturation measures with asthma and pulmonary function in Latino youth and determine whether this association varies across Latino subgroups.
Methods |
We included 1849 Latinos (302 Caribbean Spanish, 193 Central or South Americans, 1136 Mexican Americans, and 218 other Latino children) aged 8 to 21 years from 4 urban regions in the United States. Acculturation measures include nativity status, age of immigration, language of preference, and generation in the United States. We used multivariable logistic and linear regression models to quantify the association of acculturation factors with the presence of asthma (case-control study) and pulmonary function (case-only study), adjusting for demographic, socioenvironmental, and clinical variables.
Results |
For all acculturation measures (nativity status, age of immigration, language of preference, and generation in the United States), greater levels of acculturation were associated with greater odds of asthma. Among cases, high (English preference) and medium (equal preference for Spanish and English) levels of language acculturation were associated with decreased bronchodilator response compared with low (Spanish preference) levels (P = .009 and .02, respectively). Similarly, high language acculturation was associated with increased FEV1 compared with low language acculturation (P = .02). There was insufficient evidence of heterogeneity for associations across Latino subgroups.
Conclusions |
Acculturation was associated with diagnosed asthma and pulmonary function in Latino children and is an important factor to consider in the management of Latino youth with asthma.
Le texte complet de cet article est disponible en PDF.Key words : Latino, asthma, acculturation, pediatric, health disparities, social determinants of health
Abbreviation used : GALA II
Plan
| Supported in part by the Sandler Family Foundation, the American Asthma Foundation, the RWJF Amos Medical Faculty Development Program, the Harry Wm. and Diana V. Hind Distinguished Professorship in Pharmaceutical Sciences II, the National Heart, Lung, and Blood Institute (1R01HL117004, R01Hl128439, R01HL135156, and 1X01HL134589), the National Institute of Health and Environmental Health Sciences (R01ES015794 and R21ES24844), the National Institute on Minority Health and Health Disparities (1P60MD006902, U54MD009523, and 1R01MD010443), and the Tobacco-Related Disease Research Program (award no. 24RT-0025). Grant M01-RR00188 went to H.J.F., and N.T. was supported by an institutional training grant from the National Institute of General Medical Sciences (T32-GM007546) and career development awards from the National Heart, Lung, and Blood Institute (K12-HL119997 and K23-HL125551-01A1), the Parker B. Francis Fellowship Program, and the American Thoracic Society. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. |
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| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interests. |
Vol 143 - N° 5
P. 1914-1922 - mai 2019 Retour au numéro
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