Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children - 04/05/19
Doi : 10.1016/j.jaci.2018.10.071
Theresa W. Guilbert, MD, MS a 
, Leonard B. Bacharier, MD b, David T. Mauger, PhD c, Wanda Phipatanakul, MD, MS d, Stanley J. Szefler, MD e, Susan Boehmer, MA c, Avraham Beigelman, MD b, Anne M. Fitzpatrick, PhD f, Daniel J. Jackson, MD g, Sachin N. Baxi, MD d, Mindy Benson, MSN, PN h, Carey-Ann D. Burnham, PhD i, Michael D. Cabana, MD j, Mario Castro, MD, MPH b, James F. Chmiel, MD, MPH k, Ronina Covar, MD l, Michael Daines, MD m, Jonathan M. Gaffin, MD, MMSc n, Deborah A. Gentile, MD o, Fernando Holguin, MD p, Elliot Israel, MD q, H. William Kelly, PharmD r, Stephen C. Lazarus, MD j, Robert F. Lemanske, MD g, Ngoc Ly, MD s, Kelley Meade, MD h, Wayne Morgan, MD m, James Moy, MD t, J. Tod Olin, MD l, Stephen P. Peters, MD u, Jacqueline A. Pongracic, MD v, Hengameh H. Raissy, PharmD r, Kristie Ross, MD k, William J. Sheehan, MD d, Christine Sorkness, PharmD w, W. Gerald Teague, MD x, Shannon Thyne, MD y, Fernando D. Martinez, MD m
for the
, Leonard B. Bacharier, MD b, David T. Mauger, PhD c, Wanda Phipatanakul, MD, MS d, Stanley J. Szefler, MD e, Susan Boehmer, MA c, Avraham Beigelman, MD b, Anne M. Fitzpatrick, PhD f, Daniel J. Jackson, MD g, Sachin N. Baxi, MD d, Mindy Benson, MSN, PN h, Carey-Ann D. Burnham, PhD i, Michael D. Cabana, MD j, Mario Castro, MD, MPH b, James F. Chmiel, MD, MPH k, Ronina Covar, MD l, Michael Daines, MD m, Jonathan M. Gaffin, MD, MMSc n, Deborah A. Gentile, MD o, Fernando Holguin, MD p, Elliot Israel, MD q, H. William Kelly, PharmD r, Stephen C. Lazarus, MD j, Robert F. Lemanske, MD g, Ngoc Ly, MD s, Kelley Meade, MD h, Wayne Morgan, MD m, James Moy, MD t, J. Tod Olin, MD l, Stephen P. Peters, MD u, Jacqueline A. Pongracic, MD v, Hengameh H. Raissy, PharmD r, Kristie Ross, MD k, William J. Sheehan, MD d, Christine Sorkness, PharmD w, W. Gerald Teague, MD x, Shannon Thyne, MD y, Fernando D. Martinez, MD mfor the
National Heart, Lung, and Blood Institute's AsthmaNet∗
Lisa Bartnikas, MD, Alisha Bouzaher, MS, Christopher Burke, Matthew Cavanaugh, Julia Chen, PA-C, Elizabeth Cunningham, Amparito Cunningham, James Friedlander, MD, Enal Hindi, MD, David Kantor, MD, Perdita Permaul, MD, Devako Rao, MD, Melinda Rossi, MPH, Doris Schierembergg, MS, Kynda Schneider, MD, Jennifer Troung, Dale Umetsu, MD, Joseph Zhou, MD, Jill Chmielewski, Anna Fishbein, Iliana Flexas, Ramsay Fuleihan, Rajesh Kumar, James Lane, Melanie Makhija, Louis Martos, Brandon Parker, Benjamin Prince, Nashmia Qamar, Mary Riordan, Rachel Robinson, Waheeda Samady, Christine Szychlinski, Daniel Tsang, Christopher Codispoti, Juan Fu, Grace Li, Diana Munoz-Mendoza, Benjamin Thompson, Melanie Gleason, Sakari Graves, Jonathan Malka, Melanie Phillips, Gayle Spears, D. Sundstrom, Michael White, Christina Batson, BS, Lea Davies, MD, Franceska Kelly, BS, CCRC, Esmeralda Morales, MD, Abby Redway, RRT, BOE, Mary Spicher, BSN, MSN, Lauren Kaminski, BS, Megan R. Knutson, MS, RCEP, Kelly Miller, BS, CCRC, Jennifer Promer, BS, Sheila Turcsanyi, BS, CCRC, Tanya Watson, RN, BSN, Shean Aujla, MD, John Broyles, CRNP, Hey Chong, MD, Patricia Dubin, MD, Jonathan Finder, MD, Todd D. Green, MD, Lori Holt, CRNP, Adam Kufen, RN, Geoffrey Kurland, MD, Rose Lanzo, RRT, David Nash, MD, Julianne Parente, Catherine Smith, RN, Jonathan Spahr, MD, Daniel J. Weiner, MD, Daniel Craven, MD, Danielle Goetz, Meeghan Hart, MD, Leigh A. Kerns, MD, Laurie Logan, RN, Ross Myers, MD, Laura Veri, RA, Erica Butler, MBS, CCRC, Jennifer Maiolo, PA-C, Sara Misplay, MBA, CCRC, David Skoner, MD, Glennys Smith, Wanda Caldwell, MBA, RRT, BHS, Courtney Dula, MS, Alysa Ellis, MD, Caroline Horner, MD, Lila Kertz, PNP, Tina Norris, CRT, Katherine Rivera-Spoljaric, MD, Oscar Rodriguez, MD, Robert Strunk, MD, Jessica Bowman, Vicky Bowyer, Judy Gonzales-Vargas, Sara Hawkey, Susannah McCormick, Michelle McKean, Dan Shapiro, Katherine Tom, Jason Decker, RN, Keonna Harrison, Dayna Long, MD, Jyothi Marbin, MD, Robert Mok, LVN, Cindy Nelson-Purdy, NP, MPH, Dennis Ren, Hollie Stessel, CPhT, Jason Decker, RN, Keonna Harrison, Dayna Long, MD, Jyothi Marbin, MD, Robert Mok, LVN, Cindy Nelson-Purdy, NP, MPH, Dennis Ren, Hollie Stessel, CPhT, Deb Green, Denise Thompson-Batt, Kristin Wavell, Donna Wolf, Timothy Beaty, Alice C. Bruce, BS, Karen DeMuth, Jennifer Dodds, Shaneka Douglas, Dawn M. Simon, Denise Whitlock, Shanae Brown, RRT, Susan Boehmer, MA, Matthew Bowman, Loretta Doty, MSW, Linda Ferrari, BS, Beth Gern, Dave Mauger, PhD, Aimee Merchlinski, James Schmidt, Daniel Tekely, Lindsay Texter, Angela Updegrave, Ronald Zimmerman, MPA
a Department of Pediatrics, University of Cincinnati and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
b Department of Pediatrics, Washington University in St Louis School of Medicine, St Louis, Mo
c Department of Public Health Sciences, Pennsylvania State University, Hershey, Pa
d Division of Allergy/Immunology, Boston Children's Hospital, Boston, Mass
e Breathing Institute, Children's Hospital Colorado, Denver, Colo
f Department of Pediatrics, Emory University, Atlanta, Ga
g Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wis
h Benioff Children's Hospital, Oakland, Calif
i Department of Pathology and Immunology, Washington University in St Louis School of Medicine, St Louis, Mo
j Departments of Medicine and Pediatrics, University of California, San Francisco, San Francisco, Calif
k Rainbow Babies and Children's Hospital, Cleveland, Ohio
l Department of Pediatrics, National Jewish Health, Denver, Colo
m Arizona Respiratory Center, University of Arizona, Tucson, Ariz
n Division of Respiratory Diseases, Boston Children's Hospital, Boston, Mass
o Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pa
p University of Pittsburgh Asthma Institute, Pittsburgh, Pa
q Brigham and Women's Hospital, Boston, Mass
r Department of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM
s Airway Clinical Research Center, University of California, San Francisco, San Francisco, Calif
t Stroger Hospital of Cook County Pediatric Services, Chicago, Ill
u Wake Forest University School of Medicine, Winston-Salem, NC
v Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Ill
w University of Wisconsin-Madison, Madison, Wis
x University of Virginia School of Medicine, Charlottesville, Va
y Department of Pediatrics, San Francisco General Hospital, San Francisco, Calif
| Disclosure of potential conflict of interest: T. W. Guilbert reports personal fees from the American Board of Pediatrics–Pediatric Pulmonary Subboard, GlaxoSmithKline, Regeneron Pharmaceuticals, Merck, Novartis/Regeneron, Aviragen, GlaxoSmithKline/Regneron, and TEVA; grants from the National Institutes of Health (NIH); grants and personal fees from Sanofi/Regenero; and other support from UpToDate outside the submitted work. L. B. Bacharier reports grants from the NIH during the conduct of the study and reports personal fees from Aerocrine, GlaxoSmithKline, Genentech/Novartis, Merck, DBV Technologies, Teva, Boehringer Ingelheim, AstraZeneca, WebMD/Medscape, Sanofi/Regeneron, Vectura, and Circassia outside the submitted work. D. T. Mauger reports grants from the National Heart, Lung, and Blood Institute (NHLBI) during the conduct of the study and has received nonfinancial support from GlaxoSmithKline, Merck, TEVA, and Boehringer Ingelheim outside the submitted work. W. Phipatanakul reports grants from the NIH during the conduct of the study, reports grants and other support from Genentech and GlaxoSmithKline, and reports other support from Novartis, Teva, and Sanofi/Regeneron. S. J. Szefler reports grants and other from NHLBI AsthmaNet during the conduct of the study and reports grants from GlaxoSmithKline and other support from Boehringer Ingelheim, Genentech, GlaxoSmithKline, Aerocrine, AstraZeneca, Daiichi Sankyo, Roche, Teva, and Propeller Health outside the submitted work. A. Beigelman and A. M. Fitzpatrick report grants from the NIH during the conduct of the study. D. J. Jackson reports grants from the NHLBI during the conduct of the study and reports grants from the National Institute of Allergy and Infectious Diseases (NIAID), personal fees from Vectura, Boehringer Ingelheim, and Pfizer, and grants and personal fees from GlaxoSmithKline outside the submitted work. M. D. Cabana reports personal fees from Novartis, Genentech, and Phadea outside the submitted work. M. Castro receives University Grant Funding from the NIH, American Lung Association, and PCORI; receives pharmaceutical grant funding from AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Novartis, and Sanofi Aventis; is a consultant for Aviragen, Boston Scientific, Genentech, Nuvaira, Neutronic, Therabron, Theravance, Vectura, 4D Pharma, VIDA, Mallincrodt, Teva, and Sanofi-Aventis; is a speaker for AstraZeneca, Boehringer Ingelheim, Boston Scientific, Genentech, Regeneron, Sanofi, and Teva; and receives royalties from Elsevier. J. F. Chmiel reports grants from the NIH during the conduct of the study and reports personal fees from the American Board of Pediatrics, the Cystic Fibrosis Foundation, Albumedix, Catabasis, Patara Pharma, and Paka Pharma; reports nonfinancial support from GlaxoSmithKline, Teva, Merck, Sunovion, Corbus Pharmaceuticals, and Vertex Pharmaceuticals; and reports grants from the Cystic Fibrosis Foundation outside the submitted work. R. Covar reports grants from GlaxoSmithKline and Novartis outside the submitted work. E. Israel reports personal fees from AstraZeneca, Novartis, Regeneron Pharmaceuticals, Bird Rock Bio, Nuvelution Pharmaceuticals, Vitaeris, Sanofi Genzyme, Merck, Entrinsic Health Solutions, GlaxoSmithKline, Pneuma Respiratory, 4D Pharma, Sienna Biopharmaceutical, and Equillium; reports personal fees and other from TEVA Specialty Pharmaceuticals; reports grants from Genentech, Sanofi, and Boehringer Ingelheim; reports nonfinancial support from Boehringer Ingelheim, GlaxoSmithKline, Merck, Sunovion, TEVA, and TEVA Specialty Pharmaceuticals; and reports other support from Vorso Corp outside the submitted work. S. C. Lazarus reports grants from the NIH/NHLBI during the conduct of the study. R. F. Lemanske, Jr, reports grants from the NHLBI during the conduct of the study; reports nonfinancial support from the American Academy of Allergy, Asthma & Immunology; reports grants from the Clinical and Translational Science Award from the NIH, Childhood Origins of Asthma (COAST), and AsthmaNet; and reports personal fees from LSU, Elsevier, UpToDate, the EAACI, the Japanese Society of Allergology, and the APAAACI and APAPARI outside the submitted work. N. Ly reports grants from Vertex 2018 and Vertex 2017 and personal fees from Gilead and has a patent null pending. W. Morgan reports grants from the NIH/NHLBI during the conduct of the study and reports grants from the Cystic Fibrosis Foundation, the NIH/NIAID and the NIH/NHLBI; and reports personal fees from Genentech, the Cystic Fibrosis Foundation, and the American College of Chest Physicians outside the submitted work. J. Moy reports grants from the NIH/NHLBI during the conduct of the study. S. P. Peters reports grants from the NIH/NHLBI during the conduct of the study and reports personal fees from AstraZeneca, Regeneron-Sanofi, Genentech, TEVA, Quintiles, Novartis, and Mylan outside the submitted work. J. A. Pongracic reports grants from the NHLBI (subcontract through Northwestern University Feinberg School of Medicine) during the conduct of the study and reports other support from GlaxoSmithKline and Novartis outside the submitted work. K. Ross reports nonfinancial support from Boehringer Ingelheim, GlaxoSmithKline, and Merck; grants and nonfinancial support from TEVA; and grants from Flamel, Jazz, and the NHLBI outside the submitted work. C. Sorkness reports grants from the NIAID and NHLBI during the conduct of the study. W. G. Teague reports grants from the NIH/NHLBI and TEVA Respiratory and personal fees from Genentech outside the submitted work. F. D. Martinez reports grants from the NIH/NHLBI during the conduct of the study; reports grants from the NIH/NHLBI, NIH/National Institute of Environmental Health Sciences, NIH/NIAID, and NIH/Office of Director, and Johnson & Johnson; and reports personal fees from Copeval and Commense outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2019
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 143 - N° 5
P. 1934 - mai 2019 Retour au numéro
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