Desensitization to rabies is a result of successfully eliminating canine rabies in the United States, which occurred in 2007; however, the need for mandatory rabies vaccination in pets remains. Rabies cases are rare in comparison with other vaccine-preventable diseases in companion animals; however, because it is a zoonotic disease with the highest case fatality rate of any infectious disease demands the establishment of strict laws for disease prevention. Preventive strategies include addressing current concerns in consideration of disease surveillance, appropriate vaccination recommendations, and local regulations protecting public health.