High-Dose Vitamin D Supplementation Does Not Prevent Allergic Sensitization of Infants - 23/05/19
, Anna S. Pelkonen, MD, PhD 2, 3, Otto Helve, MD, PhD 1, 2, Helena Hauta-alus, MSc 1, 2, Elisa Holmlund-Suila, MD, PhD 1, 2, Saara Valkama, MD 1, 2, Maria Enlund-Cerullo, MD 1, 2, Heli Viljakainen, PhD 4, 5, Timo Hytinantti, MD, PhD 1, 2, Outi Mäkitie, MD, PhD 1, 2, 4, Sture Andersson, MD, PhD 1, 2, Mika J. Mäkelä, MD, PhD 2, 3Abstract |
Objective |
To investigate the effect of vitamin D supplementation dose on allergic sensitization and allergic diseases in infants, and to evaluate whether vitamin D status in pregnancy and at birth are associated with infant allergy outcomes.
Study design |
Altogether, 975 infants participated in a randomized, controlled trial of daily vitamin D supplementation of 10 μg (400 IU) or 30 μg (1200 IU) from the age of 2 weeks. At 12 months of age, food and aeroallergen IgE antibodies were measured, and the occurrence of allergic diseases and wheezing were evaluated.
Results |
We found no differences between the vitamin D supplementation groups in food (OR, 0.98; 95% CI, 0.66-1.46) or aeroallergen sensitization at 12 months (OR, 0.76; 95% CI,0.34-1.71). Allergic diseases or wheezing did not differ between groups, except for milk allergy which occurred more often in infants administered 30 μg vitamin D compared with the 10 μg dose (OR, 2.23; 95% CI, 1.00-4.96). Infants with high cord blood 25-hydroxyvitamin D (≥100 nmol/L) had a higher risk of food allergen sensitization compared with those with lower 25(OH)D concentration (75-99.9 nmol/L; OR, 2.00; 95% CI, 1.19-3.39).
Conclusions |
High-dose vitamin D supplementation did not prevent allergic sensitization, allergic diseases, or wheezing during the first year of life. In contrast, we observed an increased risk of milk allergy in infants randomized to higher vitamin D supplementation, and an increased risk of allergic sensitization in infants with high cord blood vitamin D status, indicating a possible adverse effect of high concentrations of vitamin D.
Le texte complet de cet article est disponible en PDF.Keywords : IgE, wheezing, food allergy, intervention
Abbreviation : 25(OH)D
Plan
| Supported by the Foundation for Pediatric Research, Finska Läkaresällskapet, the Finnish Medical Foundation, Governmental Subsidy for Clinical Research, the Päivikki and Sakari Sohlberg Foundation, Stiftelsen Dorothea Olivia, Karl Walter och Jarl Walter Perkléns minne, the Academy of Finland, the Sigrid Jusélius Foundation, the Folkhälsan Research Foundation, the Novo Nordisk Foundation, the Orion Research Foundation, Barncancerfonden, and Allergy Research Foundation. The funders had no role in the design and conduct of the study; collection, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication. The authors declare no conflicts of interest. |
Vol 209
P. 139 - juin 2019 Retour au numéro
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