Special Considerations for the Aging Brain and Perioperative Neurocognitive Dysfunction - 21/07/19
, Pratik P. Pandharipande, MD, Christopher G. Hughes, MDRésumé |
Postoperative delirium and postoperative cognitive dysfunction (POCD) occur commonly in older adults after surgery and are frequently underrecognized. Delirium has been associated with worse outcomes, and both delirium and cognitive dysfunction increase the risk of long-term cognitive decline. Although the pathophysiology of delirium and POCD have not been clearly defined, risk factors for both include increasing age, lower levels of education, and baseline cognitive impairment. In addition, developing delirium increases the risk of POCD. This article examines interventions that may reduce the risk of developing delirium and POCD and improve long-term recovery and outcomes in the vulnerable older population.
Le texte complet de cet article est disponible en PDF.Keywords : Postoperative delirium, Postoperative cognitive dysfunction, Neuroinflammation, Long-term cognitive impairment, Geriatric anesthesia
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| Disclosure: Dr Pandharipande received support from the National Institutes of Health (HL111111, GM120484). Dr Hughes received support from American Geriatrics Society Jahnigen Career Development Award and the National Institutes of Health (HL111111, AG045085, GM120484). |
Vol 37 - N° 3
P. 521-536 - septembre 2019 Retour au numéro
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