Correlation between the DEPDC5 rs1012068 polymorphism and the risk of HBV-related hepatocellular carcinoma - 25/07/19
, Xiaolin Zhang a, Lei Yang a, Dianwu Liu a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | A total of 1289 samples were enrolled, including healthy controls, Hepatitis B chronic (CHB), liver cirrhosis (LC), HBV-related HCC patients. |
• | SNPs in the DEPDC5 rs1012068 were detected using MALDI-TOF-MS. |
• | Discovered that DEPDC5 rs1012068 was correlated with the progress of HBV-related HCC for the first time. |
• | Provide a better comprehending of the molecular biology mechanisms of HCC. |
Summary |
Introduction |
HBV and/or HCV infection is the main cause of hepatocellular carcinoma (HCC), but the molecular mechanisms by which HBV promotes HCC are not clear. In 2011, the result of a GWAS revealed a common variant of DEPDC5 affected HCC susceptibility in patient with chronic HCV infection in Japan. This study investigated the correlation between DEPDC5 polymorphism and HBV-related HCC.
Materials and methods |
1289 samples of Han population were involved in northern China and peripheral blood samples were obtained, including 506 healthy controls, 217 Hepatitis B chronic (CHB) and 258 liver cirrhosis (LC), and 308 HBV-related HCC patients. SNPs in the DEPDC5 rs1012068 were detected by MALDI-TOF-MS.
Results |
After controlling for the influence of sex, smoking and drinking, this study showed a significant relationship between the polymorphism of DEPDC5 rs1012068 and HBV-related HCC. Healthy participants with CC genotype showed 2.008 (95% CI = 1.145, 3.520; P = 0.015) times more likely to develop HCC; CHB cases with CC genotype showed 2.241 (95% CI = 1.226, 4.461; P = 0.022) times more likely to develop HCC; LC cases with CC genotype showed 2.706 (95% CI = 1.371, 5.340; P = 0.004) times more likely to develop HCC; and individuals with AC genotype showed 1.615 (95% CI = 1.110, 2.352; P = 0.012) times more likely to develop HCC.
Conclusions |
There was a significant correlation between DEPDC5 rs1012068A/C and HBV-related HCC in the Han Chinese population. A to C mutation increased the risk of the developing of HBV-related HCC.
Le texte complet de cet article est disponible en PDF.Keywords : DEPDC5, Polymorphisms, Hepatitis B virus, Hepatocellular carcinoma
Plan
Vol 43 - N° 4
P. 446-450 - août 2019 Retour au numéro
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