Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study - 31/07/19
Abstract |
Study objective |
To evaluate the influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium after pars plana vitrectomy (PPV) under general anesthesia.
Design |
Prospective, double-blind, randomized controlled trial.
Setting |
This study was conducted in a University Teaching Hospital from February to July 2017.
Patients |
A total of 84 patients with an American Society of Anesthesiologists physical status of I or II who were scheduled to undergo PPV under general anesthesia.
Interventions |
The patients were randomly assigned to the neostigmine (Group N, n = 44) or sugammadex (Group S, n = 40) groups; 3 ml of study drug was prepared for the patients. For patients in Group N, a solution of neostigmine methylsulfate (1 mg) and glycopyrrolate (0.2 mg) was prepared, while a solution of sugammadex sodium (2 mg/kg) and normal saline was prepared for patients in Group S.
Measurements |
The primary endpoint was the effect of sugammadex, compared with neostigmine, on the recovery rate in the physiological domain in patients who underwent PPV with general anesthesia. The quality of recovery was assessed using the Postoperative Quality Recovery Scale at 15 min and 40 min after surgery, and on postoperative day 1.
Main results |
The recovery rate in the physiological domain was higher in Group S at 15 min after surgery (P = 0.020). Though there were no significant differences in the overall cognitive recovery domain, patients in Group S could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the scale.
Conclusions |
The use of sugammadex may increase the quality of physiological recovery at early postoperative periods, compared with that of neostigmine, following a single bolus dose of rocuronium in patients undergoing PPV with general anesthesia.
Trial Registration: Registered at ClinicalTrials.gov (NCT03108989). Registration number: NCT03108989.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Reversal of neuromuscular blockade was performed with sugammadex and neostigmine. |
• | Recovery quality after pars plana vitrectomy under general anesthesia was assessed. |
• | The recovery rate in physiological domain was higher for sugammadex. |
• | Sugammadex may improve the quality of early postoperative physiological recovery. |
Keywords : Anesthesia recovery period, Neostigmine, Neuromuscular blockade, Sugammadex
Plan
Vol 57
P. 97-102 - novembre 2019 Retour au numéro
Article précédent
- Postoperative cognitive dysfunction is rare after fast-track hip- and knee arthroplasty — But potentially related to opioid use
- Hussein Nasser Awada, Iben Engelund Luna, Henrik Kehlet, Heidi Raahauge Wede, Susanne Jung Hoevsgaard, Eske Kvanner Aasvang
- Cost-benefit analysis of the use of tranexamic acid in total replacement hip surgery
- Amanda Lopez-Picado, Borja Barrachina, Maria Remón, Maria Errea
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?