HIV Diagnostics : Current Recommendations and Opportunities for Improvement - 06/08/19
Résumé |
Profound changes in technology have revolutionized laboratory testing for human immunodeficiency virus (HIV) since the first laboratory enzyme immunoassays that detected only immunoglobulin G (IgG) antibodies. Instrumented fourth-generation random-access chemiluminescent assays are now recommended for initial screening because they become reactive in as little as 2 weeks after infection. Using HIV-1 RNA viral load assays after a reactive initial test could confirm infection and provide useful clinical information. Early initiation of antiretroviral therapy and use of preexposure prophylaxis can alter the evolution of biomarkers and assay reactivity, leading to ambiguous test results.
Le texte complet de cet article est disponible en PDF.Keywords : HIV testing, HIV antibody test, HIV diagnosis, HIV testing algorithm, HIV viral load
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| Disclosure Statement: Dr B.M. Branson has served as a consultant to Chembio Diagnostic Systems Inc and Gilead Sciences, Inc. From 2003 to 2014, Dr. Branson was Associate Director for Laboratory Diagnostics in the Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention. |
Vol 33 - N° 3
P. 611-628 - septembre 2019 Retour au numéro
Article précédent
- Nearly Two Decades Later, Exciting Progress in HIV, But Challenges Remain
- Paul E. Sax
- Antiretroviral Medications for the Prevention of HIV Infection : A Clinical Approach to Preexposure Prophylaxis, Postexposure Prophylaxis, and Treatment as Prevention
- Amila Heendeniya, Isaac I. Bogoch
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