Gastroenteritis, Hepatitis, Encephalopathy, and Human Herpesvirus 6 Detection in an Immunocompetent Child: Benefits and Risks of Syndromic Multiplex Molecular Panel Testing - 19/08/19
Doi : 10.1016/j.jpeds.2019.04.058
Christina A. Olson, MD 1, 2, ⁎ 
, Samuel R. Dominguez, MD, PhD 1, 2, Steve Miller, MD, PhD 3, Charles Y. Chiu, MD, PhD 3, 4, 5, Kevin Messacar, MD 1, 2
, Samuel R. Dominguez, MD, PhD 1, 2, Steve Miller, MD, PhD 3, Charles Y. Chiu, MD, PhD 3, 4, 5, Kevin Messacar, MD 1, 2 1 Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO
2 Children's Hospital Colorado, Aurora, CO
3 Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA
4 University of California San Francisco—Abbott Laboratories Viral Diagnostics and Discovery Center, San Francisco, CA
5 Division of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, CA
∗Reprint requests: Christina A. Olson, MD, Children's Hospital Colorado, 13123 E 16th Ave, B270, Aurora, CO 80045.Children's Hospital Colorado13123 E 16th AveB270AuroraCO80045
Abstract |
An immunocompetent toddler came to medication attention with gastroenteritis, complicated by encephalopathy and hepatitis. Multiplexed testing using a polymerase chain reaction meningitis panel was positive for human herpesvirus 6 (HHV-6). Clinical correlation, quantitative HHV-6 polymerase chain reaction, and metagenomic next-generation sequencing supported a likely diagnosis of primary HHV-6B infection.
Le texte complet de cet article est disponible en PDF.Keywords : HHV-6, BioFire FilmArray, roseola
Abbreviations : CSF, HHV-6, mNGS, PCR
Plan
| Supported by National Institutes of Health (1K23AI128069-01), the Charles and Helen Schwab Foundation, the George and Judy Marcus Foundation, and the California Initiative to Advance Precision Medicine. These funding sources had no role in study design or writing of the manuscript and the views expressed are solely those of the authors. The authors declare no conflicts of interest. |
© 2019
Elsevier Inc. Tous droits réservés.
Vol 212
P. 228-231 - septembre 2019 Retour au numéro
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