Key points : Immunologic aspects of atheroma
The pathogenesis of atherosclerosis remains incompletely understood.
Accumulation of oxidized lipoproteins (oxLDL) within the vascular wall drives a related immune response very early during the disease course.
Such an immune response is self-amplified and eventually escapes from physiologic control mechanisms.
Certain lymphocytes may become pathogenic.
B cells play a protective role by producing antibodies able to neutralize oxLDL.
Elucidation of the immune control mechanisms in atherosclerosis will open the way to new therapeutic perspectives.
© 2006 Elsevier Masson SAS. Tous droits réservés.