Genetic risk scores do not improve asthma prediction in childhood - 05/09/19
Doi : 10.1016/j.jaci.2019.05.017
F. Nicole Dijk, MD, PhD a, b, Charlotte Folkersma a, b, Olena Gruzieva, MD, PhD c, d, Ashish Kumar, PhD c, e, f, Alet H. Wijga, PhD g, Ulrike Gehring, PhD h, Inger Kull, PhD i, j, Dirkje S. Postma, MD, PhD k, Judith M. Vonk, PhD b, l, Erik Melén, MD, PhD c, i, Gerard H. Koppelman, MD, PhD a, b 
a Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
b Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
c Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
d Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden
e Department of Public Health Epidemiology, Swiss Tropical and Public Health Institute, Basel, Switzerland
f University of Basel, Basel, Switzerland
g Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
h Center for Nutrition, Prevention, and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
i Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden
j Department of Clinical Science and Education, Södersjukhuset and Karolinska Institutet, Stockholm, Sweden
k Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
l Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
| Supported by The Netherlands Lung Foundation (grant no. 3.2.09.081JU), Stichting Astma Bestrijding, and the Ubbo Emmius Foundation. The BAMSE project was supported by the Swedish Research Council, Swedish Heart-Lung Foundation, Stockholm County Council (ALF project), and European Commission (GABRIEL Project: 018996). |
|
| Disclosure of potential conflict of interest: D. S. Postma declares that the University of Groningen has received money on his behalf regarding a grant for research from AstraZeneca, Chiesi, Genentech, GlaxoSmithKline, and Roche; fees for consultancies were given to the University of Groningen by AstraZeneca, Chiesi, and GlaxoSmithKline. G. K. Koppelman received grants from the Lung Foundation of the Netherlands, BBMRI-NL, and the UBBO Emmius Foundation during the conduct of the study and received grants from Lung Foundation of The Netherlands, GlaxoSmithKline, the Tetri Foundation, Vertex, an TEVA (The Netherlands) outside the submitted work. The rest of the authors declare that they have no relevant conflict of interests. |
© 2019
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 144 - N° 3
P. 857 - septembre 2019 Retour au numéro
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