Reply - 05/09/19

Doi : 10.1016/j.jaci.2019.05.029

Juan Carlos Cardet, MD, MPH ^a, Xiaofeng Jiang, PhD ^b,^c, Quan Lu, PhD ^b,^c, Norma Gerard, PhD ^d, Kristen McIntire, MPH ^a, Homer A. Boushey, MD ^e, Mario Castro, MD, MPH ^f, Vernon M. Chinchilli, PhD ^g, Christopher D. Codispoti, MD, PhD ^h,ⁱ, Anne-Marie Dyer, MS ^g, Fernando Holguin, MD, MPH ^j, Monica Kraft, MD ^k, Stephen Lazarus, MD ^e, Robert F. Lemanske, MD ^l,^m, Njira Lugogo, MD ⁿ, Dave Mauger, PhD ^g, Wendy C. Moore, MD ^o, James Moy, MD ^h,ⁱ, Victor E. Ortega, MD, PhD ^o, Stephen P. Peters, MD, PhD ^o, Lewis J. Smith, MD ^p, Julian Solway, MD ^q, Christine A. Sorkness, PharmD ^l,^m, Kaharu Sumino, MD, MPH ^f, Michael E. Wechsler, MD, MMSc ^r, Sally Wenzel, MD ^j, Elliot Israel, MD ^a
for the
AsthmaNet Investigators
^a Department of Medicine, Brigham and Women's Hospital, Boston, Mass
^b Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass
^c Department of Genetics, and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Mass
^d Department of Pediatrics, Boston Children's Hospital, Boston, Mass
^e Department of Medicine, University of California San Francisco, San Francisco, Calif
^f Department of Medicine, Washington University, St Louis, Mo
^g Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pa
^h Department of Medicine, Rush University Medical Center, Chicago, Ill
ⁱ Department of Pediatrics, Stroger Hospital of Cook County, Chicago, Ill
^j Department of Medicine, Pittsburgh University, Pittsburgh, Pa
^k Department of Medicine, University of Arizona, Tucson, Ariz
^l Department of Medicine, University of Wisconsin, Madison, Wis
^m Department of Pharmacy Practice, University of Wisconsin, Madison, Wis
ⁿ Department of Medicine, Duke University, Durham, NC
^o Department of Internal Medicine, Wake Forest University, Winston-Salem, NC
^p Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill
^q Department of Medicine, University of Chicago, Chicago, Ill
^r Department of Medicine, National Jewish University, Denver, Colo

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	Supported by grants HL098102, U10HL098096, UL1TR000150, UL1TR000430, UL1TR000050, HL098075, UL1TR001082, HL098090, HL098177, UL1TR000439, HL098098, UL1TR000448, HL098107, HL098112, HL098103, UL1TR000454, and HL098115 awarded by the National Heart, Lung, and Blood Institute.
	Disclosure of potential conflict of interest: J. C. Cardet reports grants from the National Institute of Allergy and Infectious Diseases (NIAID) during the conduct of the study. M. Castro reports grants from the National Institutes of Health (NIH) and American Lung Association during the conduct of the study and personal fees from Aviragen, Boehringer Ingelheim, Boston Scientific, Elsevier, Genentech, GlaxoSmithKline, Holaira, and Teva; grants from Amgen, Boehringer Ingelheim, Genentech, Gilead, GlaxoSmithKline, Invion, MedImmune, sanofi-aventis, and Vectura all outside the submitted work. V. M. Chinchilli, S. P. Peters, and S. Lazarus report grants from the NIH/National Heart, Lung, and Blood Institute (NHLBI) during the conduct of the study. A.-M. Dyer reports grants from the NHLBI during the conduct of the study. M. Kraft reports grants from the NIH, Roche, Sanofi, and Chiesi and other support from TEVA, AstraZeneca, and Elsevier outside the submitted work. R. F. Lemanske reports grants from the NHLBI during the conduct of the study; nonfinancial support from the American Academy of Allergy, Asthma & Immunology (AAAAI); grants from the Clinical and Translational Science Award from the NIH; personal fees from LSU, Elsevier, and UpToDate; and grants from Childhood Origins of Asthma (COAST) and AsthmaNet outside the submitted work. N. Lugogo reports personal fees from AstraZeneca and consulting fees from TEVA, outside the submitted work. D. Mauger reports grants from the NIH during the conduct of the study and nonfinancial support from GlaxoSmithKline, Merck, and TEVA outside the submitted work. W. C. Moore reports grants from the NIH/NHLBI during the conduct of the study, grants and personal fees from AstraZeneca and Sanofi Regeneron, and grants from Boehringer Ingelheim, GlaxoSmithKline, Pearl Therapeutics, and Novartis outside the submitted work. J. Solway reports consulting fees from Sanofi, Genzyme, and Regeneron and gifts from the Rafael Rivera III Memorial Foundation for Asthma Research to the University of Chicago that were designated for asthma research in his laboratory. M. E. Wechsler reports personal fees from AstraZeneca, BSCI, Novartis, Vectura, Regeneron, Genentech, Sentien, and Boehringer Ingelheim and grants and personal fees from Teva, GlaxoSmithKline, and Sanofi, all outside the submitted work. S. Wenzel reports grants and personal fees from AstraZeneca and Sanofi; grants from Boehringer Ingelheim, GlaxoSmithKline, and Novartis; and personal fees from Pieris and UpToDate outside the submitted work. E. Israel reports personal fees from AstraZeneca, Novartis, Philips Respironics, Regeneron Pharmaceuticals, TEVA Specialty Pharmaceuticals, Bird Rock Bio, Nuvelution Pharmaceuticals, Vitaeris, Sanofi, Merck, Entrinsic Health Solutions, and GlaxoSmithKline; other support from Vorso, Pneuma Respiratory, and 4D Pharma; grants from Genentech, Sanofi, and Boehringer Ingelheim; and nonfinancial support from Boehringer Ingelheim, GlaxoSmithKline, Merck, Sunovion, TEVA, and TEVA Specialty Pharmaceuticals outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest.
	Trial registration: Clinicaltrials.gov Identifier: NCT02230332.