Chronic stress induces persistent low-grade inflammation - 26/09/19
, Camille G. Apple a , Kolenkode B. Kannan a , Zackary M. Funk b , Jessica M. Plazas c , Philip A. Efron a , Alicia M. Mohr a, ⁎ Abstract |
Introduction |
This study sought to determine if the systemic cytokine profile of rodents subjected to chronic restraint stress leads to persistent low-grade inflammation.
Methods |
Male Sprague-Dawley rats were subjected to restraint stress for a total of seven or fourteen days. Urine norepinephrine (NE), plasma interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP) were assessed with ELISA. Liver expression of IL-6 and TNF-α were assessed with real time PCR.
Results |
Chronic stress at 7 and 14 days sequentially increased plasma acute phase reactants (NE, IL-6, TNF-α, and CRP), liver IL-6 expression, hematopoietic progenitor cell mobilization, and decreased erythroid progenitor colony growth. Weight gain was reduced by chronic stress compared to each models’ naïve counterpart.
Conclusions |
Combining this model with trauma and sepsis models will allow evaluation of the contribution of persistent inflammation in disease progression and outcomes.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A daily restraint stress model can produce a low grade inflammatory state. |
• | Daily restraint stress increased norepinephrine and inflammatory cytokines. |
• | Daily restraint stress was associated with reduced weight gain. |
• | Adding stress to injury models can mirror the impact of the critical illness. |
Keywords : Inflammation, Stress, Norepinephrine, IL-6, C-reactive protein
Plan
Vol 218 - N° 4
P. 677-683 - octobre 2019 Retour au numéro
Article précédent
- Clinical and pathological stage discordance among 433,514 breast cancer patients
- Jennifer K. Plichta, Samantha M. Thomas, Amanda R. Sergesketter, Rachel A. Greenup, Oluwadamilola M. Fayanju, Laura H. Rosenberger, Nina Tamirisa, Terry Hyslop, E. Shelley Hwang
- Roux-en-Y gastric bypass is a safe and effective option that improves major Co-Morbidities associated with obesity in an older, veteran population
- Victoria Lyo, Anne L. Schafer, Lygia Stewart
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?