Postexercise Heart Rate Recovery in Adults Born Preterm - 23/10/19
, Marika Sipola, MD, PhD 1, 3, Antti M. Kiviniemi, PhD 4, Marjaana Tikanmäki, MD, PhD 1, 3, Marjo-Riitta Järvelin, MD, PhD 2, 5, 6, 8, Johan G. Eriksson, MD, PhD 1, 7, 9, Mikko P. Tulppo, PhD 4, Marja Vääräsmäki, MD, PhD 2, 3, 4, Eero Kajantie, MD, PhD 1, 3, 9, 10Abstract |
Objective |
To evaluate postexercise heart rate recovery (HRR) in adults born preterm.
Study design |
We studied the association between preterm birth and postexercise HRR in 545 adults (267 women) at 23.3 years of age (range 19.9-26.3 years). One hundred three participants were born early preterm (<34 completed weeks), 178 late preterm (34-36), and 264 were full term (control group). HRR was calculated as change in heart rate (HR) 30 seconds and 60 seconds after cessation of submaximal step test and maximum HR slope during the first minute after.
Results |
Mean peak HR was 159.5 bpm in the early preterm (P = .16 with controls), 157.8 bpm in the late preterm (P = .56), and 157.0 bpm in the control group. Mean HRR 30 seconds after exercise was 3.2 bpm (95% CI 1.1-5.2) lower in the early preterm group and 2.1 bpm (0.3-3.8) lower in the late preterm group than the full term controls. Mean 60s HRR was 2.5 (−0.1 to 5.1) lower in the early preterm group and 2.8 bpm (0.6-4.9) lower in the late preterm group. Mean maximum slope after exercise was 0.10 beats/s (0.02-0.17) lower in the early preterm group and 0.06 beats/s (0.00-0.12) lower in the late preterm group.
Conclusions |
Our results suggest reduced HRR after exercise in adults born preterm, including those born late preterm. This suggests altered reactivation of the parasympathetic nervous system, which may contribute to cardiovascular risk among adults born preterm.
Le texte complet de cet article est disponible en PDF.Keywords : premature birth, autonomic control, sympathetic, parasympathetic, gestational age, birth weight
Abbreviations : BMI, ESTER, HR, HRR, HRR30s, HRR60s, VLBW
Plan
| The ESTER study was supported by grants from the Academy of Finland (SALVE program for 2009–2012 and grants 127437, 129306, 130326, 134791, and 263924 [to E.K.]); University of Oulu Graduate School (to R.K.); the Doctoral Program for Public Health, University of Tampere (to M.S.); the Emil Aaltonen Foundation (to E.K.); Paulo Foundation and the Finnish Foundation for Cardiovascular Research (to A.K.); the European Commission (Framework 5 award QLG1-CT-2000-001643 and Horizon 2020 award 633595 DynaHealth [to M-R.J.]; Horizon2020 award 733280 RECAP Research on Children and Adults Born Preterm [to E.K.]); the Finnish Foundation for Pediatric Research (to E.K.); the Jalmari and Rauha Ahokas Foundation (to E.K.); the Juho Vainio Foundation (to R.K, E.K., M.T., and M.V); the National Graduate School of Clinical Investigation (to M.T.); the Novo Nordisk Foundation (to E.K. and M.V.); the Signe and Ane Gyllenberg Foundation (to E.K.); the Sigrid Jusélius Foundation (to E.K.); and the Yrjö Jahnsson Foundation (to E.K., M.S., and M.V.). The authors declare no conflicts of interest. |
Vol 214
P. 89 - novembre 2019 Retour au numéro
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