Antinuclear Antibody Tests - 26/10/19
, Mandakolathur Murali, MD a, c, dRésumé |
The presence of antinuclear antibodies (ANAs), which include autoantibodies to extractable nuclear antigens (ENAs), in the sera of patients with connective tissue diseases provides useful immunologic and pathophysiologic insight into the nature of their disease. This article discusses the most commonly used diagnostic modalities for detecting and quantitating the presence of ANA: indirect immunofluorescence assay, enzyme-linked immunosorbent assay, and multiplex bead technology, which serve as useful screening tests. We also review testing for autoantibodies to ENAs, which are often helpful to confirm the diagnosis of a specific connective tissue disease.
Le texte complet de cet article est disponible en PDF.Keywords : Antinuclear antibodies, ANA, SS-A, SS-B, RNP, Sm, Jo-1, Scl70
Plan
| Disclosure Statement: The authors have nothing to disclose. |
Vol 39 - N° 4
P. 513-524 - décembre 2019 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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