Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results - 05/11/19
Doi : 10.1016/j.jaci.2019.09.013
Alec James Redwood, PhD a, Francois Rwandamuriye, MS a, Abha Chopra, PhD a, Shay Leary, BSc a, Ramesh Ram, PhD a, Wyatt McDonnell, PhD b, Katherine Konvinse, PhD c, Katie White, MD, PhD b, Rebecca Pavlos, PhD a, David M. Koelle, MD d, e, f, g, h, Simon Mallal, MBBS a, b, c, Elizabeth J. Phillips, MD a, b, c, i 
a Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia
b Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenn
c Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn
i Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tenn
d Department of Medicine, University of Washington, Seattle, Wash
e Department of Global Health, University of Washington, Seattle, Wash
h Department of Laboratory Medicine, University of Washington, Seattle, Wash
f Benaroya Research Institute, Seattle, Wash
g Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle
| Supported by National Institutes of Health grants P50 GM115305, K12 HL143956, R21 AI139021, P30 Al110527, F30 AI131780, and T32 GM7347; the National Health & Medical Research Council (Australia); and the Australian Centre for HIV & Hepatitis Research (ACH2). |
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| Disclosure of potential conflict of interest: A. Chopra, K. Konvinse, S. Mallal, and E. J. Phillips have a patent pending for HLA-A*32:01 testing for vancomycin drug reaction and eosinophilia and systemic symptoms. S. Mallal and E. J. Phillips receive royalties from UpToDate and have equity in IIID Pty Ltd, which holds a patent for HLA-B*57:01 testing for abacavir hypersensitivity. E. J. Phillips receives consulting fees from Biocryst. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2019
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 144 - N° 5
P. 1413 - novembre 2019 Retour au numéro
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