Platelet dysfunction on thromboelastogram is associated with severity of blunt traumatic brain injury - 21/11/19
, David S. Morris a , Dave S. Collingridge b , Sarah Majercik a Abstract |
Background |
Platelet dysfunction associated with isolated traumatic brain injury (TBI) can be measured using thromboelastography-platelet mapping (TEG-PM). We hypothesized that platelet dysfunction can be detected after blunt TBI, and the degree of dysfunction is associated with increased TBI severity and in-hospital mortality.
Methods |
This was a retrospective review of adult trauma patients admitted to a single level 1 trauma center from August 2013 to March 2015 who suffered isolated severe blunt TBI. Subjects were included if they received a TEG-PM within 24 h from injury, and excluded if on preinjury antiplatelet medications.
Results |
119 subjects were analyzed. Severe TBI subjects (AIS-head 5) had ADPi 18.4 points higher than moderate TBI subjects (AIS-head 3) (p = 0.001). Platelet dysfunction was not associated with TBI progression. ADPi significantly predicted mortality (OR 1.033; 95% CI 1.005–1.061, p = 0.02).
Conclusion |
Platelet dysfunction occurs immediately after isolated blunt TBI, is more pronounced with increasing TBI severity, and is associated with higher odds of in-hospital mortality. Further investigation is needed to determine whether this is a marker of disease severity or a therapeutic target.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Platelet dysfunction on thromboelastography occurs early after isolated blunt traumatic brain injury. |
• | The degree of platelet dysfunction correlates with severity of brain injury. |
• | Platelet dysfunction after isolated blunt traumatic brain injury is associated with increased odds of in-hospital mortality. |
Plan
Vol 218 - N° 6
P. 1134-1137 - décembre 2019 Retour au numéro
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