Type-1 diabetes shapes working memory processing strategies - 30/11/19

Doi : 10.1016/j.neucli.2019.09.003

Francisco Javier Alvarado-Rodríguez ^a, Rebeca Romo-Vázquez ^b, Geisa Bearitz Gallardo-Moreno ^a, Hugo Vélez-Pérez ^b, Andrés Antonio González-Garrido ^a,^⁎,^{^{1
http://www.ineuro.cucba.udg.mx/.}}
^a Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, 180 Francisco de Quevedo, 44130, Guadalajara, Jalisco, Mexico
^b Departamento de Ciencias Computacionales, CUCEI, Universidad de Guadalajara, 1421 Boulevard Marcelino García Barragán, 44430, Guadalajara, Jalisco, Mexico

^⁎Corresponding author at: Instituto de Neurociencias, Universidad de Guadalajara, Francisco de Quevedo 180, Colonia Arcos Vallarta, Guadalajara, Jalisco, 44130, Mexico.Instituto de Neurociencias, Universidad de GuadalajaraFrancisco de Quevedo 180, Colonia Arcos VallartaGuadalajaraJalisco44130Mexico

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Summary

Background

Type 1 diabetes (T1D) is a metabolic disorder characterized by recurrent hypo- and hyperglycemic episodes, whose clinical development has been associated with cognitive and working memory (WM) deficits.

Objective

To contrast quantitative electroencephalography (qEEG) measures between young patients with T1D and healthy controls while performing a visuospatial WM task with two memory load levels and facial emotional stimuli.

Methods

Four or five neutral or happy faces were sequentially and pseudo-randomly presented in different spatial locations, followed by subsequent sequences displaying the reversed spatial order or any other. Participants were instructed to discriminate between these two alternatives during EEG recording.

Results

A significant increase in the absolute power of the delta and theta bands, distributed mainly over the frontal region was found during task execution, with a slight decrease of alpha band power in both groups but mainly in control individuals. However, these changes were more pronounced in the T1D patients, and reached their maximum level during the WM encoding phase, even on trials with the lower memory load. In contrast, changes seemed to occur more gradually in controls and results differed significantly only on the trials with the higher WM load.