Longitudinal Analysis of Pulmonary Function in Survivors of Congenital Diaphragmatic Hernia - 13/12/19
Abstract |
Objective |
To analyze longitudinal trends of pulmonary function testing in patients with congenital diaphragmatic hernia (CDH) followed in our multidisciplinary clinic.
Study design |
This was a retrospective cohort study of CDH patients born between 1991 and 2013. A linear mixed effects model was fitted to estimate the trends of percent predicted forced expiratory volume in 1 second (FEV1pp), percent predicted forced vital capacity (FVCpp), and FEV1/FVC over time.
Results |
Of 268 patients with CDH who survived to discharge, 119 had at least 1 pulmonary function test study. The FEV1pp (P < .001), FVCpp (P = .017), and FEV1/FVC (P = .001) decreased with age. Compared with defect size A/B, those with defect size C/D had lower FEV1pp by an average of 11.5% (95% CI, 2.9%-20.1%; P = .010). A history of oxygen use at initial hospital discharge also correlated with decreased FEV1pp by an average of 8.0% (95% CI, 1.2%-15.0%; P = .023).
Conclusions |
In a select cohort of CDH survivors, average pulmonary function declines with age relative to expected population normative values. Those with severe CDH represent a population at risk for worsening pulmonary function test measurements who may benefit from recognition and monitoring for complications.
Le texte complet de cet article est disponible en PDF.Keywords : congenital diaphragmatic hernia, pulmonary function test, FEV1, FVC, linear mixed effects model
Abbreviations : CDH, ECMO, FEV1, FEV1pp, FVC, FVCpp, PFT
Plan
| Funded by the National Institutes of Health (5T32HL007734 [to D.D.] and 5K23HL136851 [to L.H.]). The funders had no role in study design, data analysis, decision to publish, or preparation of the manuscript. The authors declare no financial conflict of interest. |
Vol 216
P. 158 - janvier 2020 Retour au numéro
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