Methadone versus morphine for postoperative pain in patients undergoing surgery for gynecological cancer: A randomized controlled clinical trial - 11/01/20
, Fabrizio David, MD a, Patrizia Villari, MD a, Vincenza Manuela Spedale, MD a, Alessandra Casuccio, BS bAbstract |
Study objective |
The aim of this study was to compare methadone and morphine for the management of postoperative.
Design |
Open, controlled study.
Setting |
Postoperative recovering area, ward.
Patients |
Sixty-four patients, ASA I-III, undergoing gynecological surgery for cancer.
Interventions |
Morphine or methadone 0.15 mg/kg given preoperatively. After operation an intravenous morphine or intravenous methadone infusion at doses of 12 mg/day was started.
Measurements |
Pain intensity and opioid consumption.
Main results |
Methadone infusion provided a better analgesia in comparison with morphine infusion on the second day. Opioid consumption was significantly lower in the methadone group. No episodes of relevant desaturation or signs of respiratory depression were recorded.
Conclusion |
A preoperative bolus of methadone, followed by a continuous infusion of low doses post-operatively, provided a better analgesia, without adding risk of adverse effects, in comparison with morphine.
Le texte complet de cet article est disponible en PDF.Highlights |
• | A preoperative bolus of methadone, followed post-operatively by a continuous infusion of low doses provided a potent and better analgesia than morphine in gynecological surgery. |
• | The risks of adverse effects with methadone was similar to those produced by morphine. |
• | Methadone could be a relevant resource for postoperative pain. |
Keywords : Postoperative pain, Morphine, Methadone, Opioids, Gynecological cancer
Plan
| ☆ | This paper was written according to CONSORT recommendations (Fig. 1). The study was not registered, as it is not requested in our country. It was prepared before 2015, when most journals introduced the need to register trials. Moreover, there were no changes of the original protocol and all data of this trial have been included and were not replied in other studies, as redundant publication. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
Vol 61
Article 109627- mai 2020 Retour au numéro
Article précédent
- Comparison of clinical outcomes of acetaminophen IV vs PO in the peri-operative setting for laparoscopic inguinal hernia repair surgeries: A triple-blinded, randomized controlled trial
- Alopi Patel, Poonam Pai B.H., Dina Diskina, Brittany Reardon, Yan H. Lai
- Effects of remote ischemic preconditioning on regional cerebral oxygen saturation in patients in the beach chair position during shoulder surgery: A double-blind randomized controlled trial
- Chung-Sik Oh, Mijung Sa, Hyun Jun Park, Liyun Piao, Kyung-Soo Oh, Seong-Hyop Kim
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?