Multiple Sclerosis and the Choroid Plexus: Emerging Concepts of Disease Immunopathophysiology - 25/01/20
Abstract |
Background |
The coexistence of multiple sclerosis and intracranial neoplasms is very rare, and whether this occurrence can be explained by a causal relationship or by coincidence remains a matter of debate. Possible roles of the choroid plexus as a site of tumor cell invasion and lymphocyte infiltration into the central nervous system have been hypothesized in recent studies.
Methods |
We describe a 13-year-old boy with concurrent multiple sclerosis and choroid plexus papilloma, then review the published literature with a focus on the pathophysiologic mechanisms of neuroinflammation in multiple sclerosis and the potential role of the choroid plexus in this process.
Results |
A growing body of evidence suggests that both physical and functional dysregulation of the choroid plexus may be a common mechanism underlying the pathophysiology of central nervous system inflammation.
Conclusions |
In multiple sclerosis, the choroid plexus could act as a gateway for lymphocyte entry from the peripheral blood into the central nervous system at its earlier stages. However, future studies are needed to identify whether structural alterations of the choroid plexus play a role in the pathophysiology of multiple sclerosis and to provide suitable models to determine their consequences.
Le texte complet de cet article est disponible en PDF.Keywords : Multiple sclerosis, Choroid plexus, Papilloma, Pediatric, Autoimmune
Plan
| Author Disclosures: All authors report no disclosures relevant to the content of this manuscript. The manuscript has been approved by all authors and represents valid work; neither this manuscript nor one with substantially similar content under my authorship has been published or is being considered for publication elsewhere. We certify that we are the sole authors of this article and hereby take public responsibility for the entire content of the manuscript. |
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| Conflict of interest and source of funding statement: The authors declare no conflict of interest or financial disclosures concerning the materials or methods used in this study or the findings specified in this article. |
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| Ethical Approval: Because this report does not contain identifying or protected health information, ethical approval was not obtained. |
Vol 103
P. 65-75 - février 2020 Retour au numéro
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