Elevated eosinophils, IL5 and IL8 in induced sputum in asthma patients with accelerated FEV1 decline - 05/02/20
, Luka Camlek, Sabina Škrgat, Izidor Kern, Matjaž Fležar, Manca Dežman, Peter KorošecAbstract |
Background |
Some patients with asthma present with accelerated lung function decline. This phenomenon is mostly associated with severe exacerbations and with poor asthma control.
Objective |
Our aim was to detect the extent of FEV1 decline in patients with mild asthma and to discriminate clinical, functional and inflammatory factors associated with accelerated FEV1 decline.
Methods |
We recruited 50 patients with mild asthma for pulmonary function testing and induced sputum sampling 12–15 years after the initial diagnosis. In 33 patients, from whom sputum of a good quality was obtained, inflammatory cells were counted and concentrations of cytokines IL-2, IL-4, IL-5, IL-8, IL-10, IFN-γ, angiogenin and VEGF in the sputum were measured by cytometric bead array.
Results |
Eighteen of 33 patients presented with accelerated FEV1 decline of more than 30 ml/year, with a mean (SEM) of 43.2 (3.9) ml/year, compared to 15 control patients with a FEV1 decline of 14.4 (2.1) ml/year. In the accelerated FEV1 decline group, we found elevated sputum levels of IL5 with a median (IQR) of 1.8 (0.4–3.2) pg/ml vs. 0.2 (0.1–1.2) pg/ml, p = 0.04; IL8 with a mean (SEM) of 1503 (194) pg/ml vs. 938 (177) pg/ml, p = 0.04; and eosinophils with a median (IQR) of 223 (41–1020) cells/μl vs. 39 (1–190) cells/μl, p = 0.03. No significant differences in other measured parameters were detected between the two groups.
Conclusion |
Elevated sputum eosinophils, IL5 and IL8, which have a potential to stimulate airway remodelling, might be a useful non-invasive biomarkers and therapeutic targets of accelerated FEV1 decline in asthma patients.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Significant part of patients with mild asthma present with accelerated FEV1 decline. |
• | Accelerated FEV1 decline was associated with eosinophils in induced sputum. |
• | Patients with accelerated FEV1 decline had increased IL5 and IL8 in induced sputum. |
• | Eosinophils, IL5, IL8 have potential to directly influence airway remodelling. |
• | Eosinophils, IL5, IL8 potential biomarkers and therapeutic targets of remodelling. |
Keywords : Asthma, Lung function decline, Eosinophils, IL5, IL8
Abbreviations : FEV1, FVC, TI, FeNO, PD20, post BD, IL, IL5-R, VEGF, IFNγ, TGFβ, BAL, ASM, TNNC, ICS, LABA, SABA, ACT, BMI, SEM, IQR, p
Plan
| ☆ | Elevated IL5 and IL8 and eosinophils in induced sputum in asthma patients with accelerated FEV1 decline. |
Vol 162
Article 105875- février 2020 Retour au numéro
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