African walnuts attenuate ectopic fat accumulation and associated peroxidation and oxidative stress in monosodium glutamate-obese Wistar rats - 11/02/20
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Graphical abstract |
Highlights |
• | African walnuts decreased lipid accumulation in adipose and ectopic tissues in MSG-obese rats. |
• | African walnuts decreased lipid peroxidation in the adipose tissues, brain, kidneys and heart of MSG-obese rats. |
• | African walnuts increase antioxidant activities in the adipose tissues, brain, kidneys and heart of MSG-obese rats. |
Abstract |
Aims |
African walnuts were previously shown to modulate hepatic lipid bio-accumulation in obesity. Herein, we investigated the impact of the nuts on fat accumulation in adipose and ectopic regions, and associated oxidatiive stress status in obese rats.
Materials and methods |
Whole ethanol extract (WE) of the nuts, and its liquid-liquid fractions-ethyl acetate (ET) and residue (RES) were separately administered to obese rats for 6 weeks. The normal (NC) and obese (OC) controls received normal saline and the standard control (SC), orlistat (5.14 mg/kg b.w.), during the same period. Thereafter, the animals were euthanized and the adipose, brain, kidneys and heart tissues were studied.
Results |
The change in body weight to naso-anal length which increased by 63.52 % in OC compared to NC (p < 0.05), decreased by 57.88, 85.80 and 70.20 % in WE, ET and RES-treated groups, respectively, relative to the OC (p < 0.05). Also, adipose tissue weights were lowered upon treatment with the extracts and fractions versus OC (p < 0.05). Total lipids, phospholipids, triacylglycerol and cholesterol concentrations in the studied tissues which were higher in OC (p < 0.05) were lowered (p < 0.05) and compared favorably with SC. Further, malondialdehyde levels in the tissues were lowered upon treatment, compared to the OC (p < 0.05). Glutathione level and activities of glutathione peroxidase, superoxide dismutase and glutathione-S-transferase which were decreased (p < 0.05) in OC, were restored upon treatment with the extracts, relative to the obese control (p < 0.05).
Significance |
African walnuts assuaged lipogenesis, oxidative stress and peroxidation in extra-hepatic tissues of obese rats, hence, may attenuate ectopic fat accumulation and its associated pathogenesis.
Le texte complet de cet article est disponible en PDF.Abbreviations : BMI, BW, ET, GPx, GSH, GST, MSG, NAL, NC, OC, RES, SC, SOD, TBAR, WE
Keywords : Tetracarpidium conophorum, Obesity, Tissue peroxidation, Extra-hepatic lipids, Tissue anti-oxidants
Plan
Vol 124
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