Regulation of nitric oxide production in hypothyroidism - 11/02/20
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Abstract |
Hypothyroidism is a common endocrine disorder that predominantly occurs in females. It is associated with an increased risk of cardiovascular diseases (CVD), but the molecular mechanism is not known. Disturbance in lipid metabolism, the regulation of oxidative stress, and inflammation characterize the progression of subclinical hypothyroidism. The initiation and progression of endothelial dysfunction also exhibit these changes, which is the initial step in developing CVD. Animal and human studies highlight the critical role of nitric oxide (NO) as a reliable biomarker for cardiovascular risk in subclinical and clinical hypothyroidism. In this review, we summarize the recent literature findings associated with NO production by the thyroid hormones in both physiological and pathophysiological conditions. We also discuss the levothyroxine treatment effect on serum NO levels in hypothyroid patients.
Le texte complet de cet article est disponible en PDF.Abbreviation : ADMA, Akt, AMPK, CAMK2B, CVD, sGC, cGMP, CRP, CVS, ED, eNOS, GTP, HDL, IL, iNOS, I, L, LDL, LT4, MAPK, MetS, NO, NOS, nNOS, PI3K, PKA, PKG, T3, T4, THRα, TSH, TNF, VASP, VSMC
Keywords : Nitric oxide, Hypothyroidism, Cardiovascular diseases, Endothelial dysfunction, Levothyroxine
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Vol 124
Article 109881- avril 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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