Hashimotos’ thyroiditis: Epidemiology, pathogenesis, clinic and therapy - 13/03/20
: Research Fellow, Biologist, Clinical Pathologist, Poupak Fallahi b : Researcher, Assistant Professor, Giusy Elia a : Research Fellow, Biologist, Clinical Pathologist, Debora Gonnella a : Laboratory Technician, Sabrina Rosaria Paparo a : Biologist, Claudia Giusti a : Laboratory Technician, Leonid P. Churilov, MD, PhD c , Silvia Martina Ferrari a : Researcher, Biologist, Clinical Pathologist, Alessandro Antonelli a, ⁎ : Director: Immuno-Endocrine Section of Internal Medicine, Professor of Medicine, Endocrinology, Clinical Pathology, Head, Laboratory of Primary Human CellsAbstract |
Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disorders (AITDs), is the leading cause of hypothyroidism in the iodine-sufficient areas of the world. About 20–30% of patients suffers from HT, whose cause is thought to be a combination of genetic susceptibility and environmental factors that causes the loss of immunological tolerance, with a consequent autoimmune attack to the thyroid tissue and appearance of the disease.
The pathologic features of lymphocytic infiltration, especially of T cells, and follicular destruction are the histological hallmark of autoimmune thyroiditis (AIT), that lead to gradual atrophy and fibrosis. An important role in the immune-pathogenesis of AITDs is due to chemokines and cytokines.
In about 20% of patients, AITDs are associated with other organ specific/systemic autoimmune disorders.
Many studies have demonstrated the relationship between papillary thyroid cancer and AITD.
The treatment of hypothyroidism, as result of AIT, consists in daily assumption of synthetic levothyroxine.
Le texte complet de cet article est disponible en PDF.Keywords : autoimmune diseases, autoimmune thyroid disorders, autoimmune thyroiditis, Hashimoto's thyroiditis, hypothyroidism, levothyroxine
Plan
Vol 33 - N° 6
Article 101367- décembre 2019 Retour au numéro
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