Behavior Profiles at 2 Years for Children Born Extremely Preterm with Bronchopulmonary Dysplasia - 20/03/20
Doi : 10.1016/j.jpeds.2019.12.028
Jane E. Brumbaugh, MD 1, Edward F. Bell, MD 2, Scott F. Grey, PhD 3, Sara B. DeMauro, MD, MSCE 4, Betty R. Vohr, MD 5, Heidi M. Harmon, MD, MS 2, Carla M. Bann, PhD 6, Matthew A. Rysavy, MD, PhD 2, J. Wells Logan, MD 7, Tarah T. Colaizy, MD, MPH 2, Myriam A. Peralta-Carcelen, MD 8, Elisabeth C. McGowan, MD 5, Andrea F. Duncan, MD 9, Barbara J. Stoll, MD 9, Abhik Das, PhD 3, Susan R. Hintz, MD, MS Epi 10
for the
for the
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network∗
Michael S. Caplan, MD, Richard A. Polin, MD, Abbot R. Laptook, MD, Martin Keszler, MD, Angelita M. Hensman, PhD, RNC-NIC, Elisa Vieira, RN, BSN, Emilee Little, RN, BSN, Robert T. Burke, MD, MPH, Bonnie E. Stephens, MD, Barbara Alksninis, RNC, PNP, Carmena Bishop, Mary L. Keszler, MD, Teresa M. Leach, MEd, CAES, Victoria E. Watson, MS, CAS, Andrea M. Knoll, Michele C. Walsh, MD, MS, Avroy A. Fanaroff, MD, Nancy S. Newman, RN, Deanne E. Wilson-Costello, MD, Allison Payne, MD, MSCR, Monika Bhola, MD, Gulgun Yalcinkaya, MD, Bonnie S. Siner, RN, Harriet G. Friedman, MA, Elizabeth Roth, MS, William E. Truog, MD, Eugenia K. Pallotto, MD, MSCE, Howard W. Kilbride, MD, Cheri Gauldin, RN, BS, CCRC, Anne Holmes, RN, MSN, MBA-HCM, CCRC, Kathy Johnson, RN, CCRC, Allison Knutson, RN, BSNC-NIC, Kurt Schibler, MD, Brenda B. Poindexter, MD MS, Stephanie Merhar, MD MS, Kimberly Yolton, PhD, Teresa L. Gratton, PA, Cathy Grisby, BSN, CCRC, Kristin Kirker, CRC, Sandra Wuertz, RN, BSN, CLC, David P. Carlton, MD, Ira Adams-Chapman, MD, Ellen C. Hale, RN, BS, CCRC, Yvonne C. Loggins, RN, BSN, Diane I. Bottcher, RN, MSN, Colleen Mackie, BS, RRT, Sheena L. Carter, PhD, Maureen Mulligan LaRossa, RN, Lynn C. Wineski, RN, MS, Gloria V. Smikle, PNP, MSN, Angela Leon-Hernandez, MD, Salathiel Kendrick-Allwood, MD, C. Michael Cotten, MD, MHS, Ronald N. Goldberg, MD, Ricki F. Goldstein, MD, William F. Malcolm, MD, Patricia L. Ashley, MD, Joanne Finkle, RN, JD, Kimberley A. Fisher, PhD, FNP-BC, IBCLC, Sandra Grimes, RN, BSN, Kathryn E. Gustafson, PhD, Matthew M. Laughon, MD, MPH, Carl L. Bose, MD, Janice Bernhardt, MS RN, Gennie Bose, RN, Diane Warner, MD, MPH, Janice Wereszczak, CPNP-AC/PC, Stephen D. Kicklighter, MD, Ginger Rhodes-Ryan, ARNP, MSN, NNP-BC, Rosemary D. Higgins, MD, Stephanie Wilson Archer, MA, Brenda B. Poindexter, MD MS, Gregory M. Sokol, MD, Lu Ann Papile, MD, Abbey C. Hines, PsyD, Dianne E. Herron, RN, Susan Gunn, NNP, CCRC, Lucy Smiley, CCRC, Kathleen A. Kennedy, MD, MPH, Jon E. Tyson, MD, MPH, Julie Arldt-McAlister, RN, BSN, Katrina Burson, RN, BSN, Allison G. Dempsey, PhD, Patricia W. Evans, MD, Carmen Garcia, RN, CCRP, Margarita Jiminez, MD, MPH, Janice John, CPNP, Patrick M. Jones, MD, MA, M. Layne Lillie, RN, BSN, Karen Martin, RN, Sara C. Martin, RN, BSN, Georgia E. McDavid, RN, Shawna Rodgers, RN, BSN, Saba Khan Siddiki, MD, Daniel Sperry, RN, Patti L. Pierce Tate, RCP, Sharon L. Wright, MT (ASCP), Pablo J. Sánchez, MD, Leif D. Nelin, MD, Sudarshan R. Jadcherla, MD, Patricia Luzader, RN, Christine A. Fortney, PhD, RN, Gail E. Besner, Nehal A. Parikh, MD, Dennis Wallace, PhD, Marie G. Gantz, PhD, Jamie E. Newman, PhD, MPH, Jeanette O'Donnell Auman, BS, Margaret Crawford, BS, Jenna Gabrio, BS, CCRP, David Leblond, BS, Carolyn M. Petrie Huitema, MS, Kristin M. Zaterka-Baxter, RN, BSN, Krisa P. Van Meurs, MD, Valerie Y. Chock, MD, MS, Epi, David K. Stevenson, MD, Marian M. Adams, MD, M. Bethany Ball, BS, CCRC, Barbara Bentley, PsychD, MS, Ed, Maria Elena DeAnda, PhD, Anne M. Debattista, RN, PNP, PhD, Beth Earhart, PhD, Lynne C. Huffman, MD, Magdy Ismael, MD, MPH, Casey E. Krueger, PhD, Andrew W. Palmquist, RN, BSN, Melinda S. Proud, RCP, Elizabeth N. Reichert, MA, CCRC, Meera N. Sankar, MD, Nicholas H. St. John, PhD, Heather L. Taylor, PhD, Hali E. Weiss, MD, Ivan D. Frantz, MD, John M. Fiascone, MD, Brenda L. MacKinnon, RNC, Ellen Nylen, RN, BSN, Anne Furey, MPH, Cecelia E. Sibley, PT MHA, Ana K. Brussa, MS, OTR/L, Waldemar A. Carlo, MD, Namasivayam Ambalavanan, MD, Kirstin J. Bailey, PhD, Fred J. Biasini, PhD, Monica V. Collins, RN, BSN, MaEd, Shirley S. Cosby, RN, BSN, Vivien A. Phillips, RN, BSN, Richard V. Rector, PhD, Sally Whitley, MA, OTR-L, FAOTA, Uday Devaskar, MD, Meena Garg, MD, Isabell B. Purdy, PhD, CPNP, Teresa Chanlaw, MPH, Rachel Geller, RN, BSN, Neil N. Finer, MD, Yvonne E. Vaucher, MD, MPH, David Kaegi, MD, Maynard R. Rasmussen, MD, Kathy Arnell, RNC, Clarence Demetrio, RN, Martha G. Fuller, RN, MSN, Wade Rich, BSHS RRT, Radmila West, PhD, Michelle L. Baack, MD, Dan L. Ellsbury, MD, Laurie A. Hogden, MD, Jonathan M. Klein, MD, John M. Dagle, MD, PhD, Karen J. Johnson, RN, BSN, Tracy L. Tud, RN, Chelsey Elenkiwich, RN, BSN, Megan M. Henning, RN, Megan Broadbent, RN, BSN, Mendi L. Schmelzel, MSN, RN, Jacky R. Walker, RN, Claire A. Goeke, RN, Michelle L. Baack, MD, Dan L. Ellsbury, MD, Laurie A. Hogden, MD, Jonathan M. Klein, MD, John M. Dagle, MD, PhD, Karen J. Johnson, RN, BSN, Tracy L. Tud, RN, Chelsey Elenkiwich, RN, BSN, Megan M. Henning, RN, Megan Broadbent, RN, BSN, Mendi L. Schmelzel, MSN, RN, Jacky R. Walker, RN, Claire A. Goeke, RN, Kristi L. Watterberg, MD, Robin K. Ohls, MD, Conra Backstrom Lacy, RN, Sandra Brown, BSN, Janell Fuller, MD, Carol Hartenberger, MPH, BSN, Jean R. Lowe, PhD, Sandra Sundquist Beauman, MSN, RNC-NIC, Mary Ruffner Hanson, RN, BSN, Tara Dupont, MD, Elizabeth Kuan, RN, BSN, Barbara Schmidt, MD, MSc, Haresh Kirpalani, MB, MSc, Aasma S. Chaudhary, BS, RRT, Soraya Abbasi, MD, Toni Mancini, RN, BSN, CCRC, Dara M. Cucinotta, RN, Judy C. Bernbaum, MD, Marsha Gerdes, PhD, Hallam Hurt, MD, Carl T. D'Angio, MD, Ronnie Guillet, MD, PhD, Gary J. Myers, MD, Satyan Lakshminrusimha, MD, Anne Marie Reynolds, MD, Michelle E. Hartley-McAndrew, MD, Holly I.M. Wadkins, MA, Michael G. Sacilowski, BS, Linda J. Reubens, RN, CCRC, Rosemary L. Jensen, Joan Merzbach, LMSW, William Zorn, PhD, Osman Farooq, MD, Deanna Maffett, RN, Ashley Williams, MS Ed, Julianne Hunn, BS, Stephanie Guilford, BS, Kelley Yost, PhD, Mary Rowan, RN, Diane M. Prinzing, AAS, Karen Wynn, NNP, RN, Cait Fallone, MA, Ann Marie Scorsone, MS, CCRC, Myra H. Wyckoff, MD, Pablo J. Sánchez, MD, Luc P. Brion, MD, Roy J. Heyne, MD, Diana M. Vasil, MSN, RN, BSNC-NIC, Sally S. Adams, MS, RN, CPNP, Lijun Chen, RN, PhD, Maria M. De Leon, RN, BSN, Frances Eubanks, RN, BSN, Alicia Guzman, Elizabeth T. Heyne, MS, MA, PA-C, PsyD, Linda A. Madden, RN, BSN, CPNP, Nancy A. Miller, RN, Lizette E. Lee, RN, Lara Pavageau, MD, Pollieanna Sepulveda, RN, Cathy Twell Boatman, MS, CIMI, Roger G. Faix, MD, Bradley A. Yoder, MD, Mariana Baserga, MD, MSCI, Karen A. Osborne, RN, BSN, CCRC, Shawna Baker, RN, Karie Bird, RN, BSN, Jill Burnett, RNC, BSN, Susan Christensen, RN, Brandy Davis, RN, Jennifer O. Elmont, RN, BSN, Jennifer J. Jensen, RN, BSN, Manndi C. Loertscher, BS, CCRP, Trisha Marchant, RNC, Earl Maxson, RN, CCRN, Stephen D. Minton, MD, D. Melody Parry, RN, Carrie A. Rau, RN, BSN, CCRC, Susan T. Schaefer, RN, BSN, RRT, Mark J. Sheffield, MD, Cynthia Spencer, RNC, BSN, Mike Steffen, PhD, Kimberlee Weaver-Lewis, RN, MS, Sarah Winter, MD, Kathryn D. Woodbury, RN, BSN, Karen Zanetti, RN, Seetha Shankaran, MD, Sanjay Chawla, MD, Beena G. Sood, MD, MS, Athina Pappas, MD, Girija Natarajan, MD, Monika Bajaj, MD, Rebecca Bara, RN, BSN, Mary E. Johnson, RN, BSN, Laura Goldston, MA, Stephanie A. Wiggins, MS, Mary K. Christensen, BA, RRT, Martha Carlson, MD, John Barks, MD, Diane F. White, RRT, CCRP, Richard A. Ehrenkranz, MD, Harris Jacobs, MD, Christine G. Butler, MD, Patricia Cervone, RN, Sheila Greisman, RN, Monica Konstantino, RN, BSN, JoAnn Poulsen, RN, Janet Taft, RN, BSN, Elaine Romano, MSN
1 Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN
2 Department of Pediatrics, University of Iowa, Iowa City, IA
3 Social, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD
4 Department of Pediatrics, University of Pennsylvania, Philadelphia, PA
5 Department of Pediatrics, Brown University, Providence, RI
6 Social, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, NC
7 Department of Pediatrics, Ohio State University, Columbus, OH
8 Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL
9 Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, TX
10 Department of Pediatrics, Stanford University, Palo Alto, CA
Abstract |
Objective |
To characterize behavior of 2-year-old children based on the severity of bronchopulmonary dysplasia (BPD).
Study design |
We studied children born at 22-26 weeks of gestation and assessed at 22-26 months of corrected age with the Child Behavior Checklist (CBCL). BPD was classified by the level of respiratory support at 36 weeks of postmenstrual age. CBCL syndrome scales were the primary outcomes. The relationship between BPD grade and behavior was evaluated, adjusting for perinatal confounders. Mediation analysis was performed to evaluate whether cognitive, language, or motor skills mediated the effect of BPD grade on behavior.
Results |
Of 2310 children, 1208 (52%) had no BPD, 806 (35%) had grade 1 BPD, 177 (8%) had grade 2 BPD, and 119 (5%) had grade 3 BPD. Withdrawn behavior (P < .001) and pervasive developmental problems (P < .001) increased with worsening BPD grade. Sleep problems (P = .008) and aggressive behavior (P = .023) decreased with worsening BPD grade. Children with grade 3 BPD scored 2 points worse for withdrawn behavior and pervasive developmental problems and 2 points better for externalizing problems, sleep problems, and aggressive behavior than children without BPD. Cognitive, language, and motor skills mediated the effect of BPD grade on the attention problems, emotionally reactive, somatic complaints, and withdrawn CBCL syndrome scales (P values < .05).
Conclusions |
BPD grade was associated with increased risk of withdrawn behavior and pervasive developmental problems but with decreased risk of sleep problems and aggressive behavior. The relationship between BPD and behavior is complex. Cognitive, language, and motor skills mediate the effects of BPD grade on some problem behaviors.
Le texte complet de cet article est disponible en PDF.Keywords : BPD, infants born premature, child behavior checklist, bayley scales of infant and toddler development, cognitive, language, motor
Abbreviations : Bayley-III, BPD, CBCL, ICH, NRN, ROP, SGA
Plan
| Funded by awards to the participating institutions from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Detailed funding information is available in the Appendix (available at www.jpeds.com). The authors declare no conflicts of interest. |
© 2019
Elsevier Inc. Tous droits réservés.
Vol 219
P. 152 - avril 2020 Retour au numéro
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