This article demonstrates how good communication sets the foundation to provide superior comprehensive care during the stressful time surrounding end of life. Communication addressing end-of-life care in veterinary medicine has significant impact on all involved: the patient, the client, the health care team, and the practice. These conversations require training and practice to achieve mutually satisfying outcomes. Suggested guides for facilitating these conversations and several typical scenarios are presented to provide methods for future evidenced-based evaluation in effective communication. The Critical Incident Stress Management is presented as a model for mitigation of adverse consequences related to traumatic events in veterinary practice.