Sensitization to grass pollen allergen molecules in a birth cohort—natural Phl p 4 as an early indicator of grass pollen allergy - 06/04/20
, Karin Åberg, MD b, c, Danijela Apostolovic, PhD a, Christian Lupinek, MD d, Pia Gattinger, PhD d, Irene Mittermann, PhD d, Niklas Andersson, MSc e, Erik Melén, MD, PhD e, f, Anna Bergström, PhD e, g, Josep M. Antó, MD, PhD h, i, j, k, Jean Bousquet, MD, PhD l, Rudolf Valenta, MD d, m, n, Magnus Wickman, MD, PhD e, Marianne van Hage, MD, PhD aon behalf of the
Mechanisms for the Development of Allergies (MeDALL) consortium
Abstract |
Background |
Grass pollen allergy is one of the most common allergies worldwide.
Objective |
The aim of this study was to evaluate the usefulness of grass pollen allergen molecules for prediction of grass pollen allergy during childhood and up to adolescence.
Method |
Questionnaire data and sera obtained from the study subjects at the ages of 4, 8, and 16 years from the population-based Barn/Children Allergy Milieu Stockholm Epidemiology birth cohort were used. Sera from 763 representative subjects with serum samples available at all 3 ages were analyzed for IgE reactivity to 8 Phleum pratense (Phl p) allergens (MeDALL [Mechanisms for the Development of Allergies] chip) and to timothy grass extract (ImmunoCAP). Allergic rhinitis to grass pollen (ARg) was defined as upper airway symptoms during grass pollen exposure.
Results |
The prevalence of sensitization to any Phl p molecule was higher compared with that to timothy extract at all 3 ages: at the age of 4 years, 9.7% versus 6.8%; at the age of 8 years, 28.4% versus 15.3%; and at the age of 16 years, 37.1% versus 27.1%. General estimating equations analyses revealed that among children sensitized at the age of 4 years, the overall odds ratio (OR) of later ARg (up to 16 years) was increased only for IgE reactivity to Phl p 1 (OR = 4.9) and natural Phl p 4 (OR = 6.9). The likelihood of later symptoms increased with the number of allergen molecules; at the age of 4 years, 2 or more molecules predicted ARg to 78% and 3 or more molecules predicted ARg to 95%. A positive test result for timothy extract predicted ARg to 70%.
Conclusions |
Natural Phl p 4 is a hitherto unrecognized early indicator of grass pollen allergy, in addition to Phl p 1. To identify grass pollen sensitization and predict later ARg, allergen molecules are of added value to timothy extract alone and may help clinicians improve prediction of grass pollen allergy.
Le texte complet de cet article est disponible en PDF.Key words : Allergen molecules, allergic rhinitis, BAMSE, grass pollen, cohort, IgE, MeDALL, microarray, Phl p 4
Abbreviations used : ARg, BAMSE, CCD, ISAC, ISU-E, MeDALL, nPhl p, OR, Phl p
Plan
| Supported by the Acta Oto-Laryngologica Foundation, the Stockholm County Council, the Swedish Asthma and Allergy Research Foundation, the Swedish Heart-Lung Foundation, the Swedish Research Council, and the European Commissionś Seventh Framework 29 Program MeDALL under grant agreement No. 261357. |
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| Disclosure of potential conflict of interest: M. Westman reports personal fees from ALK and Mylan outside the submitted work. C. Lupinek reports personal fees from Thermo Fisher Scientific outside the submitted work. I. Mittermann reports grants from the Austrian Science Fund outside the submitted work. E. Melén reports personal fees from Thermo Fisher Scientific and Novartis outside the submitted work. J. Bousquet reports personal fees from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Purina, Sanofi-Aventis, Takeda, Teva, and Uriach and shares from KYomed-Innov outside the submitted work. R. Valenta reports grants from the Austrian Science Fund and grants and personal fees from Viravaxx outside the submitted work. M. van Hage reports personal fees from Biomay AG, Hycor Biomedical LLC, Thermo Fisher Scientific, and ALK outside the submitted work. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 145 - N° 4
P. 1174 - avril 2020 Retour au numéro
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