Insulin secretion and sensitivity before and after surgical treatment for aldosterone-producing adenoma - 24/05/20
, A. So, T. Nakamura, Y. Okuno, H. Fukuoka, G. Iguchi, Y. Takahashi, K. Sakaguchi, W. Ogawa
Bienvenue sur EM-consulte, la référence des professionnels de santé.
Article gratuit.
Connectez-vous pour en bénéficier!
Abstract |
Aim |
Primary aldosteronism, which is usually caused by an aldosterone-producing tumour, affects glucose metabolism. The effects of this condition on insulin secretion and insulin sensitivity have remained unclear, however. To gain insight into the influence of primary aldosteronism on glucose tolerance, various parameters related to insulin secretion or insulin sensitivity in patients with an aldosterone-producing tumour were comprehensively analyzed.
Methods |
To assess 14 patients with an aldosterone-producing tumour, hyperglycaemic and hyperinsulinaemic–euglycaemic clamp tests as well as oral glucose tolerance tests (OGTTs) were performed before and after tumour excision. Time between presurgical analysis and surgery was 27–559 (194±132) days, and 14–142 (51±38) days between surgery and postsurgical analysis. Various parameters related to insulin secretion or sensitivity as determined by OGTT as well as hyperglycaemic and hyperinsulinaemic–euglycaemic clamp analyses were evaluated.
Results |
Surgical treatment of tumours ameliorated hypokalaemia and reduced plasma aldosterone levels. First and second phases of insulin secretion during the hyperglycaemic clamp, as well as the insulinogenic index and total insulin secretion measured during OGTT, were also improved after surgery. In addition, the insulin sensitivity index determined during the hyperinsulinaemic–euglycaemic clamp was reduced after surgery.
Conclusion |
Primary aldosteronism impairs insulin secretion.
Le texte complet de cet article est disponible en PDF.Keywords : Glucose tolerance, Insulin secretion, Insulin sensitivity, Primary aldosteronism
Abbreviations : OGTT, PA, IGT, DM, APA, NGT, IVGTT, HOMA-β, HOMA-IR, DI
Plan
Vol 46 - N° 3
P. 236-242 - juin 2020 Retour au numéro
Article précédent
- Five-year mortality in patients with diabetic foot ulcer during 2009–2010 was lower than expected
- C. Amadou, A. Carlier, C. Amouyal, O. Bourron, C. Aubert, T. Couture, E. Fourniols, G. Ha Van, S. Rouanet, A. Hartemann
- Association of transcription factor 7-like 2 gene (TCF7L2) polymorphisms with stress-related hyperglycaemia (SRH) in intensive care and resulting outcomes: The READIAB study
- A. Ben Hamou, E. Kipnis, A. Elbaz, A. Bignon, S. Nseir, F. Tamion, D. Du Cheyron, E. jaillette, B. Voisin, L. Robriquet, C. Vanbaelinghem, D. Thellier, H. Abi Rached, A. Jannin, A. Duhamel, H. Behal, F. Machuron, S. Espiard, J.-C. Preiser, S. Preau, F. Pattou, M. Jourdain
Bienvenue sur EM-consulte, la référence des professionnels de santé.