The emerging role of ferroptosis in inflammation - 30/05/20
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Highlights |
• | Ferroptosis is triggered by the excessive peroxidation of phospholipid membranes. |
• | Ferroptosis, a kind of regulated necrosis, is immunogenic. |
• | There is a complex link between ferroptosis and enzymes involved in inflammation. |
• | Ferroptosis plays a positive role in inflammation through immunogenicity. |
• | Ferroptosis inhibitors have demonstrated benefits in certain diseases due to their anti-inflammatory activity. |
Abstract |
Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.
Le texte complet de cet article est disponible en PDF.Keywords : Ferroptosis, Inflammation, Anti-inflammatory
Plan
Vol 127
Article 110108- juillet 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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