Emerging role of transcription factor EB in mitochondrial quality control - 18/06/20
pages | 10 |
Iconographies | 5 |
Vidéos | 0 |
Autres | 0 |
Graphical abstract |
The potential role and mechanisms of TFEB in MQC. TFEB affects the mutiple processes involed in MQC: ❶ activation of mitophagy, ❷ regulation of mitochondrial biogenesis, ❸ ROS clearance and ❹ balance of mitochondria fission-fusion cycle, etc.. Targeting TFEB may represent an appealing therapeutic strategy to regulate MQC.
Abstract |
Mitochondria are energy producers that play a vital role in cell survival. Mitochondrial dysfunction is involved in many diseases, including metabolic syndrome, neurodegenerative disorders, cardiomyopathies, cancer, obesity, and diabetic kidney disease, and challenges still remain in terms of treatments for these diseases. Mitochondrial quality control (MQC), which is defined as the maintenance of the quantity, morphology, and function of mitochondria, plays a pivotal role in maintaining cellular metabolic homeostasis and cell survival. Recently, growing evidence suggests that the transcription factor EB (TFEB) plays a pivotal role in MQC. Here, we systemically investigate the potential role and mechanisms of TFEB in MQC, which include the activation of mitophagy, regulation of mitochondrial biogenesis, reactive oxygen species (ROS) clearance, and the balance of mitochondria fission-fusion cycle. Importantly, we further discuss the therapeutic measures and effects aimed at TFEB on mitochondrial dysfunction-related diseases. Taken together, targeting TFEB to regulate MQC may represent an appealing therapeutic strategy for mitochondrial dysfunction related-diseases.
Le texte complet de cet article est disponible en PDF.Keywords : Transcription factor EB, Mitochondrial quality control, Mitophagy, Reactive oxygen species, Therapeutic measures
Plan
Vol 128
Article 110272- août 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?