New Comprehensive Reference Values for Arterial Vascular Parameters in Children - 03/08/20
, Cameron Slorach, RDCS a, Mikhail-Paul Cardinal, BSc c, Wei Hui, MD a, Timothy J. Bradley, MBChB d, Taisto Sarkola, MD, PhD e, Luc Mertens, MD, PhD a, b, Edgar Jaeggi, MD a, bAbstract |
Background |
Noninvasive measurements of vascular parameters can be used for the detection and risk stratification of cardiovascular diseases. Most vascular parameters are influenced by age and body size, but pediatric reference values are scarce and limited to a few parameters. The aim of this study was to develop pediatric reference values and Z score equations for a comprehensive set of vascular parameters.
Methods |
A total of 292 healthy subjects aged 0 to 18 years were prospectively recruited. Stiffness index β, pressure-strain elastic modulus, common carotid intima-media thickness, brachial flow-mediated dilation, radial augmentation index, central and right arm peripheral artery pulse-wave velocities, and pulse-wave velocity ratio were assessed. Normalization for age and anthropometric variables was performed using parametric multivariate regression modeling. Z scores were assessed for heteroscedasticity, residual association with age and body size, and distribution.
Results |
Multivariate regression models with various combinations of height, weight, and age were used to obtain Z scores that were independent of age and body size. There was no residual association between Z scores and body size, age, or body mass index. There was no significant departure from the normal distribution.
Conclusions |
The authors present reference values and Z score equations for a comprehensive set of vascular parameters during childhood. Further studies are necessary to assess their usefulness in detecting the vascular signs of subclinical atherosclerosis and chronic diseases, including congenital heart disease.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Arterial vascular parameters may help detect early cardiovascular diseases. |
• | Current pediatric reference values are scarce and limited to few vascular parameters. |
• | The authors present pediatric reference values for a full set of vascular parameters. |
• | Expressed as Z scores, vascular parameters can be used for all ages and body sizes. |
Keywords : Children, Arterial stiffness, Endothelial function, Intima-media thickness, Normal data
Abbreviations : BMI, BP, cfPWV, CPWV, crPWV, dBP, dD, PWV, sBP, sD
Plan
| Dr. Torigoe holds a scholarship from Niigata Prefectural Welfare Federation of Agricultural Cooperative, Japan. Dr. Dallaire is supported in part by unrestricted salary support from Fonds de Recherche du Québec - Santé. |
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| Conflicts of interest: None. |
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| Drs. Torigoe and Dallaire contributed equally to this work. |
Vol 33 - N° 8
P. 1014 - août 2020 Retour au numéro
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