Understanding Hippocampal Development in Young Children With Autism Spectrum Disorder - 26/08/20
Abstract |
Objective |
We examined growth trajectories of hippocampal volume (HV) in early childhood in a longitudinal cohort of male and female participants with autism spectrum disorder (ASD) and typically developing (TD) individuals, and investigated HV in those with large brains. Relations between factors potentially associated with hippocampal size and growth were investigated.
Method |
Participants received 1 to 3 structural magnetic resonance imaging scans between ages 25 and 80 months (unique participants: ASD, n =200; TD, n =110; total longitudinal scans, n = 593). HV growth during this period was examined using mixed-effects linear models. Associations between early HV and growth rates, and IQ and adaptive functioning, were evaluated.
Results |
After accounting for cerebral hemisphere volume, male participants exhibited larger left and right HV than female participants. Hippocampal growth rates did not differ by sex. In children with larger hemisphere volumes, male and female participants with ASD had relatively larger HV than TD participants of similar hemisphere volume. This effect was present in a broader group than only those with disproportionate megalencephaly (male participants with large cerebral volumes relative to body size). Right hippocampi were larger than left hippocampi in both groups and sexes. Right versus left volume differences were greater for ASD. After adjusting for hemisphere volume, male participants with ASD showed a significant positive association between right hippocampal growth and adaptive behavior.
Conclusion |
HV was relatively greater in ASD in analyses adjusting for hemisphere volume, whereas only subtle differences were observed in HV and growth between participants with ASD and TD participants in unadjusted analyses, suggesting that ASD involves atypical coupling between HV and brain size.
Le texte complet de cet article est disponible en PDF.Key words : hippocampus, longitudinal, IQ, neurogenesis, adaptive functioning
Plan
| During the conduct of this work, Dr. Reinhardt was supported by the Autism Research Training Program (T32 MH073124); Dr. Solomon was supported by R01MH106518 and R01MH103284; Dr. Amaral was supported by R01MH103371, T32 MH073124, and the Simons Foundation; Dr. Nordahl was supported by R01MH104438; Dr. Rogers was supported by T32 MH073124, HRSA 1T73MC30113-01-02, NIH 1 R01 MH100030-05, and IES R324A150211; Dr. Ghetti was supported by R21HD088928; Dr. Iosif was supported by the MIND Institute Intellectual and Developmental Disabilities Research Center (U54 HD079125); and Dr. Libero was supported by the UC President’s Postdoctoral Fellowship. |
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| Dr. Reinhardt wrote the first draft of the manuscript. Drs. Solomon, Ghetti, and Amaral designed the study. Drs. Solomon and Amaral oversaw all aspects of the data collection, analysis, and writing of the manuscript. Drs. Nordahl and Ghetti contributed to data analysis and interpretation. All authors read and commented on all manuscript drafts and approved the final version. All authors agree to be responsible for the integrity of the findings. |
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| Dr. Iosif provided statistical support as part of the MIND Institute Intellectual and Developmental Disabilities Research Center (U54 HD079125). Drs. Iosif and Ferrer served as the statistical experts for this research. |
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| Disclosure: Dr. Amaral has served as a consultant for Stemina Biomarkers Discovery and Axial Therapeutics. Drs. Reinhardt, Iosif, Libero, Heath, Rogers, Ferrer, Nordahl, Ghetti, and Solomon have reported no biomedical financial interests or potential conflicts of interest. |
Vol 59 - N° 9
P. 1069-1079 - septembre 2020 Retour au numéro
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