Bone metabolism regulation: Implications for the treatment of bone diseases - 28/08/20

Doi : 10.1016/j.biopha.2020.110494

Danqi Yao ^a,^b,^{^{1
Danqi Yao, Lianfang Huang and Jianhao Ke contributed equally to this work.}}, Lianfang Huang ^a,^b,^{^{1
Danqi Yao, Lianfang Huang and Jianhao Ke contributed equally to this work.}}, Jianhao Ke ^e,^{^{1
Danqi Yao, Lianfang Huang and Jianhao Ke contributed equally to this work.}}, Ming Zhang ^c,⁎ , Qin Xiao ^d,⁎ , Xiao Zhu ^a,^b,^f,⁎
^a Guangdong Key Laboratory for Research and Development of Natural Drugs, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, Guangdong 524023, China
^b The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang, Guangdong 524023, China
^c Department of Physical Medicine and Rehabilitation, Zibo Central Hospital, Shandong University, Zibo 255000, China
^d Department of Blood Transfusion, Peking University Shenzhen Hospital, Shenzhen 518036, China
^e College of Agriculture, South China Agricultural University, Guangzhou 510046, China
^f Southern Marine Science and Engineering Guangdong Laboratory (Zhanjiang), Zhanjiang, Guangdong, 524023, China

^⁎Corresponding authors.

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Abstract

Bone cells in the human body are continuously engaged in cellular metabolism, including the interaction between bone cells, the interaction between the erythropoietic cells of the bone marrow and stromal cells, for the remodeling and reconstruction of bone. Osteoclasts and osteoblasts play an important role in bone metabolism. Diseases occur when bone metabolism is abnormal, but little is known about the signaling pathways that affect bone metabolism. The study of these signaling pathways will help us to use the relevant techniques to intervene, so as to improve the condition. The study of these signaling pathways will help us to use the relevant techniques to intervene, so as to improve the condition. I believe they will shine in the diagnosis and treatment of future clinical bone diseases.

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Keywords : Bone resorption, Osteogenesis, Bone metabolism, Bone disease, Osseous metastasis

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Vol 129

Article 110494- septembre 2020 Retour au numéro

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