Preparation of microspheres encapsulating sorafenib and catalase and their application in rabbit VX2 liver tumor - 28/08/20
, Xiaoping Zou a, ⁎ Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Highlights |
• | TACE is extensively used in the treatment of advanced hepatocellular carcinoma. |
• | Efficacy of TACE is limited to secondary tumor hypoxia. |
• | Construction of PLGA microspheres encapsulating sorafenib (SOR) and catalase (CAT). |
• | CAT regulated tumor hypoxia microenvironment. |
Abstract |
Background |
Transcatheter arterial chemoembolization (TACE) is extensively used in the treatment of advanced hepatocellular carcinoma (HCC). However, the efficacy of TACE is usually limited to secondary tumor hypoxia and hypoxia-related tumor angiogenesis.
Methods |
In this study, poly(lactic-co-glycolic acid) (PLGA) microspheres (SOR-CAT-PLGA MSs) encapsulating sorafenib (SOR) and catalase (CAT) were prepared by double-emulsion solvent diffusion method. Sorafenib inhibits tumor angiogenesis, and catalase decomposes hydrogen peroxide (H2O2) to generate oxygen in the tumor.
Results |
In vitro and in vivo, SOR -CAT-PLGA MSs could significantly improve the efficacy of hepatic artery embolization in the treatment of rabbit VX2 liver tumors, regulate tumor hypoxia and immunosuppressive microenvironment, then achieved near-complete and rapid necrosis of liver tumors.
Conclusions |
The application of new SOR -CAT-PLGA MSs in hepatic artery chemoembolization of rabbit VX2 liver tumor is a promising approach to improve the therapeutic effect of liver tumors and has a broad clinical application prospect.
Le texte complet de cet article est disponible en PDF.Abbreviations : TACE, HCC, PLGA, SOR, CAT, H2O2, HIF-1α, FDA, MSs, CCK-8, PVA, TUNEL, DCM, DMSO, TEM, SEM, BV, BF, PS, MTT, DSA, H&E, VEGF, LSCM, ALT, AST, Cr, BUN, TBIL
Keywords : Transcatheter arterial chemoembolization, Liver tumor, Microspheres, Sorafenib, Catalase
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Vol 129
Article 110512- septembre 2020 Retour au numéro
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