Artificial intelligence (AI) in GI endoscopy holds tremendous promise to augment clinical performance, establish better treatment plans, and improve patient outcomes. Although there are promising initial applications and preliminary clinical data for AI in gastroenterology, the field is still in a very early phase, with limited clinical use. The American Society for Gastrointestinal Endoscopy has convened an AI Task Force to develop guidance around clinical implementation, testing/validating algorithms, and building pathways for successful implementation of AI in GI endoscopy. This White Paper focuses on 3 areas: (1) priority use cases for development of AI algorithms in GI, both for specific clinical scenarios and for streamlining clinical workflows, quality reporting, and practice management; (2) data science priorities, including development of image libraries, and standardization of methods for storing, sharing, and annotating endoscopic images/video; and (3) research priorities, focusing on the importance of high-quality, prospective trials measuring clinically meaningful patient outcomes.