The global meningitis genome partnership - 22/09/20
, Stephen D. Bentley b, Ray Borrow c, Holly B. Bratcher d, Sylvain Brisse e, Angela B. Brueggemann f, Dominique A. Caugant g, Jamie Findlow h, LeAnne Fox i, Linda Glennie a, Lee H. Harrison j, Odile B. Harrison d, Robert S. Heyderman k, Melissa Jansen van Rensburg f, Keith A. Jolley d, Brenda Kwambana-Adams k, Shamez Ladhani l, Marc LaForce m, Michael Levin n, Jay Lucidarme c, Neil MacAlasdair b, Jenny Maclennan d, Martin C.J. Maiden d, Laura Maynard-Smith d, Alessandro Muzzi o, Philipp Oster p, Charlene M.C. Rodrigues d, Olivier Ronveaux q, Laura Serino o, Vinny Smith a, Arie van der Ende r, Julio Vázquez s, Xin Wang i, Saber Yezli t, James M. Stuart qHighlights |
• | Current WGS collections are not representative of the global meningitis picture. |
• | A global overview of WGS data is needed for timely public health intervention. |
• | WHO roadmap to defeat meningitis is ideal stimulus to improve genomic surveillance. |
• | Global Meningitis Genome Partnership will be a major factor in facilitating this. |
Summary |
Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
Le texte complet de cet article est disponible en PDF.Keywords : Whole genome sequencing, Genome partnership, Neisseria meningitidis, Streptococcus pneumoniae, Streptococcus agalactiae, Haemophilus influenzae, Bacterial meningitis, Epidemiology
Plan
Vol 81 - N° 4
P. 510-520 - octobre 2020 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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