Association between Placental Inflammatory Pathology and Offspring Neurodevelopment at 8 Months and 4 and 7 Years of Age - 22/09/20
Abstract |
Objective |
To examine whether placental inflammatory pathology is associated with subsequent child neurodevelopment.
Study design |
We used the data of US Collaborative Perinatal Project cohort study. Placentas were examined by pathologists and child neurodevelopment was evaluated at 8 months and 4 and 7 years of age. Multivariable logistic regression modelling was used to assess the association. A mediation analysis was used to evaluate whether the association was mediated through shorter gestational age.
Results |
Multivariable analysis after adjusting for confounders showed that placental inflammatory pathology was significantly associated with low Bayley motor (adjusted OR (aOR), 2.15; 95% CI, 1.50-3.06) and mental scales (aOR, 1.51; 95% CI, 1.05-2.17) at 8 months and an IQ of 70-84 (aOR, 1.13; 95% CI, 1.01-1.26) at 4 years of age. The association diminished at 7 years of age (IQ of <70, aOR 1.20 [95% CI, 0.97-1.48]; IQ of 70-79, aOR 1.03 [95% CI, 0.89-1.18]). The mediation analysis demonstrated that associations between placental inflammatory pathology and development were primarily due to direct effects of placental inflammatory pathology rather than indirect effects of shorter gestational age.
Conclusions |
Placental inflammation was associated with adverse offspring neurodevelopment up to 4 years of age.
Le texte complet de cet article est disponible en PDF.Keywords : mediation analysis, bayley motor and mental scales, IQ
Abbreviations : CPP, SES
Plan
| Funded by the Shanghai Municipal Health Commission (GWIV.26), China; and Shanghai Jiao Tong University School of Medicine Doctoral Student Innovation Fund (BXJ201907), China. The authors declare no conflicts of interest. |
Vol 225
P. 132 - octobre 2020 Retour au numéro
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