Nutritional risk screening score is associated with omission of adjuvant chemotherapy for stage III colon cancer - 27/09/20
Abstract |
Background |
This study aimed to evaluate the association between nutritional risk screening (NRS) score and administration of adjuvant chemotherapy for stage III colon cancer.
Methods |
A total of 404 patients with stage III colon cancer who underwent curative resection between January 2012 and December 2015 were included. Patients with a preoperative high nutritional risk score (NRS ≥4) were compared with those with an NRS <4. Predictive factors for omission of adjuvant chemotherapy, and prognostic factors for overall survival (OS) were analyzed.
Results |
Eighty (19.8%) patients had a high nutritional risk (NRS ≥4). An NRS score ≥4 was associated with higher risk of omission of adjuvant chemotherapy (26.3% vs. 13.6%, p = 0.006), which was significant after adjusting for covariables (odds ratio = 1.862, p = 0.047). Multivariable survival analysis showed that omission of adjuvant chemotherapy was an independent poor prognostic factor for OS (hazard ratio = 4.060, p < 0.001).
Conclusions |
An NRS score ≥4 was associated with omission of adjuvant chemotherapy in stage III colon cancer, which resulted in poor OS.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Patients with a high nutritional risk before surgery account for a significant portion (19.8%). |
• | Preoperative high nutritional risk score was associated with higher risk of omission of adjuvant chemotherapy. |
• | Omission of adjuvant chemotherapy was an independent poor prognostic factor for overall survival. |
Keywords : Colon cancer, Nutrition, Chemotherapy, Survival
Plan
Vol 220 - N° 4
P. 993-998 - octobre 2020 Retour au numéro
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