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Bidirectional relationship between atopic dermatitis and inflammatory bowel disease: A systematic review and meta-analysis - 10/10/20

Doi : 10.1016/j.jaad.2020.05.130 
Hanjae Lee, MD a, Ji Hoo Lee b, Seong-Joon Koh, MD, PhD c, d, Hyunsun Park, MD, PhD d, e,
a Department of Dermatology, Seoul National University Hospital, Seoul, South Korea 
b Seoul National University College of Medicine, Seoul, South Korea 
c Division of Gastroenterology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea 
d Laboratory of Intestinal Mucosa and Skin Immunology, Seoul, South Korea 
e Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, South Korea 

Correspondence to: Hyunsun Park, MD, PhD, Department of Dermatology, SMG-SNU Boramae Medical Center, 20 Boramae Rd 5-gil, Dongjak-gu, Seoul 07061, Korea.Department of DermatologySMG-SNU Boramae Medical Center20 Boramae Rd 5-gil. Dongjak-guSeoul07061Korea

Abstract

Background

Recently, atopic dermatitis has been suggested as a systemic inflammatory disorder that can accompany other inflammatory diseases, including inflammatory bowel disease. However, comprehensive reviews that specifically focus on the association between inflammatory bowel disease and atopic dermatitis are lacking.

Objective

To determine the association between inflammatory bowel disease and atopic dermatitis.

Methods

We searched for relevant studies from MEDLINE, EMBASE, and the Cochrane Library from inception to November 22, 2019. Considering a potential bidirectional relationship, studies reporting inflammatory bowel disease in patients with atopic dermatitis and atopic dermatitis in patients with inflammatory bowel disease were evaluated separately.

Results

We included 10 studies with 95,291,110 patients (4 studies on the prevalence of atopic dermatitis in inflammatory bowel disease, 2 on the prevalence and incidence of inflammatory bowel disease in atopic dermatitis, and 4 on either the prevalence or incidence of inflammatory bowel disease in atopic dermatitis). Meta-analyses revealed a statistically significant association between inflammatory bowel disease and atopic dermatitis in both directions (4 studies on atopic dermatitis prevalence in inflammatory bowel disease, odds ratio 1.39, 95% confidence interval 1.28-1.50; 5 on inflammatory bowel disease prevalence in atopic dermatitis, odds ratio 1.35, 95% confidence interval 1.05-1.73; and 3 studies on inflammatory bowel disease incidence in atopic dermatitis, relative risk 1.46, 95% confidence interval 0.98-2.17).

Limitations

A small number of observational studies were reviewed.

Conclusion

Published literature suggests a bidirectional relationship between inflammatory bowel disease and atopic dermatitis.

Le texte complet de cet article est disponible en PDF.

Key words : atopic dermatitis, Crohn's disease, inflammatory bowel disease, ulcerative colitis


Plan


 Funding sources: Supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2019R1C1C1002243) and Basic Science Research Program through the NRF, funded by the Ministry of Education (NRF-2016R1D1A1B03931961 and NRF-2020R1A1F10666419).
 Conflicts of interest: None disclosed.
 IRB approval status: Exempted by the IRB of SMG-SNU Boramae Medical Center (07-2020-01).
 Reprints not available from the authors.


© 2020  American Academy of Dermatology, Inc.. Publié par Elsevier Masson SAS. Tous droits réservés.
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Vol 83 - N° 5

P. 1385-1394 - novembre 2020 Retour au numéro
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