Measuring the Serologic Response to Severe Acute Respiratory Syndrome Coronavirus 2 : Methods and Meaning - 26/10/20
, Martin S. Zand, MD, PhD b
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Résumé |
The entire spectrum of diagnostic testing, from reagent supply to test performance, has been a major focus during the coronavirus disease 2019 (COVID-19) pandemic. The hope for serologic testing is that it will provide both epidemiologic information about seroprevalence as well as individual information about previous infection. This information is particularly helpful for high-risk individuals who may be outside of the viral shedding window, such as children with suspected multisystem inflammatory syndrome. It is not yet understood whether serologic testing can be interpreted in terms of protective immunity. These concerns must be addressed using highly sensitive and specific tests.
Le texte complet de cet article est disponible en PDF.Keywords : SARS-CoV-2, COVID-19, COVID-19 serology
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| Funding: This work was supported by the National Institutes of Health Institute of Allergy, Immunology and Infectious Diseases grants R01 AI129518 and R21 AI138500 (M.S. Zand), and the University of Rochester Clinical and Translational Science Award UL1 TR002001 from the National Center for Advancing Translational Sciences of the National Institutes of Health (M.S. Zand). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. None of the mentioned funders had any role in study design, data collection and analysis, decision to publish, or preparation of the article. |
Vol 40 - N° 4
P. 603-614 - décembre 2020 Retour au numéro
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