Radiotherapy and Late Effects - 30/10/20

Doi : 10.1016/j.pcl.2020.08.001

Joshua D. Palmer, MD ^a, Matthew D. Hall, MD, MBA ^b, Anita Mahajan, MD ^c, Arnold C. Paulino, MD ^d, Suzanne Wolden, MD ^e, Louis S. Constine, MD ^f,^g,^h,^⁎
^a Department of Radiation Oncology, The James Cancer Hospital at the Ohio State University Wexner Medical Center, Nationwide Children’s Hospital, Columbus, OH, USA
^b Department of Radiation Oncology, Miami Cancer Institute and Nicklaus Children’s Hospital, Miami, FL, USA
^c Department of Radiation Oncology, The Mayo Clinic, Rochester, MN, USA
^d Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
^e Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
^f Department of Radiation Oncology, University of Rochester, Rochester, NY, USA
^g Department of Pediatrics, University of Rochester, Rochester, NY, USA
^h Department of Radiation Oncology, The Judy DiMarzo Cancer Survivorship Program, James P. Wilmot Cancer Institute, University of Rochester Medical Center, PO Box 647, Rochester, NY 14642, USA

^∗Corresponding author. Department of Radiation Oncology, The Judy DiMarzo Cancer Survivorship Program, James P. Wilmot Cancer Institute, University of Rochester Medical Center, PO Box 647, Rochester, NY 14642.Department of Radiation OncologyThe Judy DiMarzo Cancer Survivorship ProgramJames P. Wilmot Cancer InstituteUniversity of Rochester Medical CenterPO Box 647RochesterNY14642

Résumé

Advances in multimodality care for patients with pediatric cancer continues to improve long-term survival. The use of surgery, chemotherapy, and radiotherapy may lead to debilitating late effects in childhood cancer survivors. It is critically important to understand, mitigate, and screen for late effects to improve the quality of life in childhood cancer survivors. This review summarizes the use of radiotherapy in children, radiobiology of tissue injury, impact of age on late effects, important organ systems affected by radiotherapy during survivorship, and screening for radiotherapy late effects.

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Keywords : Pediatric cancer, Radiotherapy, Late effects, Radiobiology

Plan

Key points

Introduction

Radiotherapy use in pediatric oncology

Radiotherapy Modalities Used in Pediatric Cancer

Trends in Radiation Modality Usage over Time

Biological effects of radiotherapy

Pathogenesis of tumorigenesis and late radiotherapy injury

Radiation techniques to mitigate toxicity

Impact of age on radiation injury

Common organ systems effected

Central Nervous System

Eye and Ear

Endocrine System

Cardiovascular System

Pulmonary System

Hepatic/Gastrointestinal

Urinary System

Skeletal System

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Vol 67 - N° 6

P. 1051-1067 - décembre 2020 Retour au numéro

Article précédent

Late Effects in Childhood Cancer Survivors: Early Studies, Survivor Cohorts, and Significant Contributions to the Field of Late Effects
Filippa Nyboe Norsker, Camilla Pedersen, Gregory T. Armstrong, Leslie L. Robison, Mary L. McBride, Michael Hawkins, Claudia E. Kuehni, Florent de Vathaire, Julie Berbis, Leontien C. Kremer, Riccardo Haupt, Line Kenborg, Jeanette Falck Winther

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The Critical Role of Clinical Practice Guidelines and Indicators in High-Quality Survivorship After Childhood Cancer
Renée L. Mulder, Rebecca J. van Kalsbeek, Melissa M. Hudson, Roderick Skinner, Leontien C.M. Kremer

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Radiotherapy and Late Effects - 30/10/20

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