Domestic ferrets (Mustela putorius furo) are common zoologic companion animals and display specific body language and vocalizations. Social interactions, play behavior, and resting periods are important keystone in domestic ferret behavior. Specific housing and environmental enrichment are recommended to preserve the expression of normal behavior and physiology in ferrets. Presence of abnormal behaviors, including aggression, urination and defecation outside the litter box, stereotypies, and absence of play behavior, should be carefully monitored by veterinarians and ferret owners to assess ferret wellness. Specific considerations, such as deafness, poor vision, and hybridation with other mustelids, may play a role in ferret behavior.